妊娠合并重度子痫前期患者药物治疗期间应用降压药药学监护流程的干预效果

Intervention Effect of Pharmaceutical Care Process of Antihypertensive Drugs During Drug Treatment in Patients with Severe Preeclampsia During Pregnancy

目的:探讨妊娠合并重度子痫前期患者降压药药学监护流程的建立,评价其对重度子痫前期患者血压水平及母婴结局的影响。方法:择取我院2020年1月—2022年12月收治的妊娠合并重度子痫前期患者作为研究对象,采用随机数字表法分为对照组(n=77)和观察组(n=73)。对照组和观察组均给予常规治疗及护理,观察组在常规治疗及护理基础上由临床药师实施药学监护。比较两组血压水平、延长孕周时间、母婴结局及药品不良反应上报情况。结果:实施药学监护后,观察组收缩压及舒张压水平均低于对照组(P<0.05);观察组药品不良反应总上报率高于对照组(P<0.05);观察组延长孕周时间长于对照组(P<0.05);两组在分娩方式、终止妊娠时间、产后出血等方面比较,差异无统计学意义(P>0.05)。结论:实施药学监护可改善重度子痫前期患者血压水平,促进降压药物合理使用,同时有利于加强药品不良反应监测,提高药品不良反应上报例数。

Objective:To explore the establishment of the pharmaceutical care process of antihypertensive drugs for pregnant women with severe preeclampsia,and to evaluate its impact on blood pressure levels and maternal and infant outcomes in patients with severe preeclampsia.Methods:Patients with pregnancy complicated with severe preeclampsia admitted to our hospital from January 2020 to December 2022 were selected as the research objects.They were divided into control group(n=77)and observation group(n=73)by random number table method.The control group and the observation group were given routine treatment and nursing,and the observation group was given pharmaceutical care by clinical pharmacists on the basis of routine treatment and nursing.The blood pressure level,prolonged gestational weeks,maternal and infant outcomes and adverse drug reaction reporting were compared between the two groups.Results:After the implementation of pharmaceutical care,the systolic blood pressure and diastolic blood pressure in the observation group were lower than those in the control group(P<0.05);the total reporting rate of adverse drug reactions in the observation group was higher than that in the control group(P<0.05);the prolongation of gestational weeks in the observation group was longer than that in the control group(P<0.05).There was no significant difference between the two groups in the mode of delivery,the time of termination of pregnancy and postpartum hemorrhage(P>0.05).Conclusion:The implementation of pharmaceutical care can improve the blood pressure level of patients with severe preeclampsia and promote the rational use of antihypertensive drugs.At the same time,it is conducive to strengthening the monitoring of adverse drug reactions and increasing the number of reported adverse drug reactions.