孟鲁司特钠联合糠酸氟替卡松治疗变应性鼻炎的效果研究

Study on Effect of Montelukast Sodium Combined with Fluticasone Furoate in Treatment of Allergic Rhinitis

目的:探讨孟鲁司特钠联合糠酸氟替卡松治疗变应性鼻炎(Allergic rhinitis,AR)临床疗效及其对远期复发风险的影响。方法:回顾性分析天津市职业病防治院耳鼻喉科收治的AR患者70例,分为对照和观察组各35例,对照组给予孟鲁司特钠,观察组加用糠酸氟替卡松鼻用喷雾剂,连续4周。分析比较两组临床疗效、血清炎症因子及治疗后6个月复发情况。结果:治疗后,观察组鼻痒、流涕、打喷嚏及鼻塞症状评分低于对照组(P<0.05);观察组生活质量评分低于对照组(P<0.05);观察组血清IL-6、IL-8和IL-10水平低于对照组(P<0.05)。结论:孟鲁司特钠联合糠酸氟替卡松治疗AR的疗效确切,可通过改善患者血清炎症因子降低复发风险,进而提升患者生活质量。

Objective:To investigate the clinical efficacy of montelukast sodium combined with fluticasone furoate in the treatment of allergic rhinitis(AR)and its effect on long-term recurrence risk..Methods:A retrospective analysis was made on 70 AR patients admitted to otolaryngology department of Tianjin Occupational Disease Prevention and Control Institute.The patients were divided into control group and observation group,with 35 cases in each group.The control group was treated with montelukast sodium,while the observation group was treated with fluticasone furoate nasal spray for 4 weeks.The clinical efficacy,serum inflammatory factors and recurrence 6 months after treatment were analyzed and compared between the two groups.Results:After treatment,the scores of nasal itching,runny nose,sneezing and nasal congestion in the observation group were lower than those in the control group(P<0.05).The quality of life score of the observation group was lower than that of the control group(P<0.05).The levels of serum IL-6,IL-8 and IL-10 in the observation group were lower than those in the control group(P<0.05).Conclusion:Montelukast sodium combined with fluticasone furoate is effective in the treatment of AR,which can reduce the risk of recurrence by improving serum inflammatory factors and improve the quality of life of patients.