白蛋白结合型紫杉醇联合顺铂腹腔灌注治疗晚期卵巢癌的效果研究

Study on the Effect of Albumin-binding Paclitaxel Combined with Cisplatin Intraperitoneal Perfusion in the Treatment of Advanced Ovarian Cancer

目的:探究白蛋白结合型紫杉醇联合腹腔灌注疗法治疗晚期卵巢癌的临床疗效及安全性。方法:选取2019年1月—2022年1月本院收治的晚期卵巢癌患者80例,随机分为对照组和观察组,各40例。对照组行白蛋白结合型紫杉醇顺铂治疗,观察组行白蛋白结合型紫杉醇联合顺铂腹腔热灌注化疗(IHPC),比较两组临床疗效、肿瘤标志物水平、免疫功能指标及不良反应发生情况。结果:观察组近期治疗有效率为92.50%,高于对照组的75.00%(P<0.05);治疗后,观察组CEA、CA125、CA199以及HE4水平低于对照组,CD3^(+)、CD4^(+)、CD8^(+)以及NK水平高于对照组(P<0.05);两组胃肠道反应、骨髓抑制、关节酸痛、肾功能损害发生率比较,差异无统计学意义(P>0.05)。结论:对晚期卵巢癌患者行白蛋白结合型紫杉醇联合腹腔灌注疗法治疗的近期疗效良好,可调节肿瘤标志物水平与免疫功能,且安全系数较高。

Objective:To explore the clinical efficacy and safety of albumin-binding paclitaxel combined with intraperitoneal perfusion therapy in the treatment of advanced ovarian cancer.Methods:A total of 80 patients with advanced ovarian cancer admitted to our hospital from January 2019 to January 2022 were randomly divided into control group and observation group,with 40 cases in each group.The control group was treated with albumin-binding paclitaxel and cisplatin,the observation group was treated with albumin-binding paclitaxel combined with cisplatin intraperitoneal hyperthermic perfusion chemotherapy(IHPC).The clinical efficacy,tumor marker levels,immune function indicators and adverse reactions were compared between the two groups.Results:The effective rate of recent treatment in the observation group was 92.50%,which was higher than 75.00%in the control group(P<0.05).After treatment,the levels of CEA,CA125,CA199 and HE4 in the observation group were lower than those in the control group,and the levels of CD3^(+),CD4^(+),CD8^(+)and NK were higher than those in the control group(P<0.05).There was no significant difference in the incidence of gastrointestinal reaction,bone marrow suppression,joint pain and renal dysfunction between the two groups(P>0.05).Conclusion:The short-term efficacy of albumin-binding paclitaxel combined with intraperitoneal perfusion therapy in patients with advanced ovarian cancer is good,which can regulate the level of tumor markers and immune function,and the safety factor is high.