不同剂量米非司酮联合亮丙瑞林在子宫腺肌症腹腔镜术后的作用

Effect of Different Doses of Mifepristone Combined with Leuprorelin on Adenomyosis After Laparoscopic Surgery

目的:探讨小剂量米非司酮联合亮丙瑞林在子宫腺肌症腹腔镜术后的作用。方法:选取2020年3月—2021年6月在郑州市金水区总医院行子宫腺肌症腹腔镜术治疗的126例患者作为研究对象,随机分为两组,各63例。对照组、观察组分别在亮丙瑞林治疗基础上联合常规剂量与小剂量的米非司酮治疗。比较两组痛经情况、月经量、子宫体积、性激素水平、临床疗效、不良反应。结果:治疗后,观察组痛经评分、月经量、子宫体积、血清雌二醇、卵泡刺激素、黄体生成素水平低于对照组(P<0.05);观察组治疗总有效率为93.65%,高于对照组的80.95%(P<0.05);观察组和对照组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:在子宫腺肌症腹腔镜术后采用亮丙瑞林联合小剂量米非司酮相比联合常规剂量米非司酮临床疗效更为显著,有助于改善痛经、月经量、子宫体积,调节性激素,且安全性良好。

Objective:To investigate the effect of low-dose mifepristone combined with leuprorelin on adenomyosis after laparoscopic surgery.Methods:A total of 126 patients who underwent laparoscopic surgery for adenomyosis in Jinshui District General Hospital of Zhengzhou from March 2020 to June 2021 were randomly divided into two groups,with 63 patients in each group.The control group and the observation group were treated with conventional dose and low dose of mifepristone on the basis of leuprorelin treatment.The dysmenorrhea,menstrual volume,uterine volume,sex hormone level,clinical efficacy and adverse reactions were compared between the two groups.Results:After treatment,the dysmenorrhea score,menstrual volume,uterine volume,serum estradiol,follicle stimulating hormone and luteinizing hormone levels in the observation group were lower than those in the control group(P<0.05).The total effective rate of treatment in the observation group was 93.65%,which was higher than 80.95%in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group and the control group(P>0.05).Conclusion:The clinical efficacy of leuprorelin combined with low-dose mifepristone after laparoscopic surgery for adenomyosis is more significant than that of combined with conventional-dose mifepristone,which is helpful to improve dysmenorrhea,menstrual volume,uterine volume,and regulate sex hormones,with good safety.