外泌体的提取方法及其miRNA在肺癌诊断中的应用

Extraction method of exosomes and the application of its miRNA in the diagnosis of lung cancer

肺癌通常在晚期才被确诊,预后较差。早期诊断是目前改善疾病预后的主要可行策略。研究显示,外泌体miRNA与肺癌的发生发展关系密切,对肺癌有一定的诊断价值。外泌体的临床应用价值越来越凸显了开发有效提取外泌体技术的重要性。本文对外泌体的提取方法及其miRNA在肺癌诊断中的应用作一综述。

Lung cancer is usually diagnosed at an advanced stage and has a poor prognosis.Early diagnosis is the main feasible strategy to improve the prognosis of disease.Studies have shown that exosomes miRNA is closely related to the occurrence and development of lung cancer,and has certain diagnostic value for lung cancer.The clinical application value of exosomes has increasingly highlighted the importance of developing effective exosomes extraction technology.This article reviews the extraction method of exosomes and the application of its miRNA in the diagnosis of lung cancer.