结直肠癌癌因性失眠与肿瘤相关症状的相关性研究

Status of Insomnia Due to Colorectal Cancer and Its Relationship with Tumor-related Symptoms

目的:探究结直肠癌癌因性失眠与肿瘤相关症状的关系。方法:选取2021年1月至2023年1月河南大学淮河医院普通外科收治的结直肠癌患者102例进行回顾性研究,分析结直肠癌癌因性失眠的发病状况,用单因素及多因素Logistic分析影响结直肠癌癌因性失眠的因素。结果:结直肠癌患者癌因性失眠总分得分为3~48分,平均得分为(31.32±4.22)分,根据>18分作为有癌因性失眠的划分值,102例患者中癌因性失眠89例,发生率为87.25%。单因素分析结果显示,未发生癌因性失眠与发生癌因性失眠患者性别、年龄、体质量指数(BMI)、白蛋白(Alb)、白细胞计数(WBC)比较差异均无统计学意义(均P>0.05),癌因性失眠患者焦虑、抑郁、恶心呕吐、疼痛、疲劳占比均高于未发生癌因性失眠患者(P<0.05)。多因素Logistic回归分析显示,恶心呕吐、疼痛、疲劳是影响癌因性失眠的独立危险因素(P<0.05)。结论:结直肠癌癌因性失眠的发生率较高,结直肠癌癌因性失眠与肿瘤的恶心呕吐、疼痛、疲劳症状有关。

Objective:Exploring the relationship between cancer-related insomnia and tumor related symptoms in colorectal cancer.Methods:A retrospective study was conducted on 102 patients with colorectal cancer admitted to the Department of General Surgery of Huaihe Hospital of Henan University from January 2021 to January 2023 to analyze the incidence of cancer-induced insomnia of colorectal cancer,and the factors affecting cancer-induced insomnia were analyzed with univariate and multivariate Logistic analysis.Results:The total score of cancer-related insomnia in colorectal cancer patients ranged from 3 to 48 points,and the average score was(31.32±4.22) points.According to the classification value of cancer-related insomnia>18 points,89 of 102 patients had cancer-related insomnia,with an incidence of 87.25%.Univariate analysis showed that there were no significant differences in gender,age,body mass index(BMI),albumin(Alb) and white blood cell count(WBC) between patients without cancer-related insomnia and patients with cancer-related insomnia(P>0.05).The proportion of anxiety,depression,nausea and vomiting,pain and fatigue in patients with cancer-related insomnia was higher than that in patients without cancer-related insomnia(P<0.05).Multivariate Logistic regression analysis showed that nausea,omiting,pain and fatigue were independent risk factors for cancer-related insomnia(P<0.05).Conclusion:The incidence of insomnia due to colorectal cancer is high.Insomnia due to colorectal cancer is related to nausea,vomiting,pain and fatigue.