机械力刺激下牙周膜细胞对破骨细胞调控作用研究进展

Research advances in the effect of periodontal ligament cells in regulating osteoclasts under mechanical stimulation

牙周膜细胞(periodontal ligament cells,PDLCs)是牙周膜中常见的细胞,在维持牙周组织形态与功能完整性、分散牙周组织受力及维持牙周组织稳态中发挥重要作用;此外,PDLCs也是一种独特的力学感受细胞,可将其受到的机械力信号转换为生物学信号,进而调控下游细胞的生物学行为。破骨细胞(osteoclasts,OCs)是牙根吸收过程中主要的功能细胞,其活性和数量受到PDLCs的调节。文章就机械力刺激下PDLCs对OCs调控作用的研究进展做一阐述,以期为牙根吸收的预防和治疗提供新的思路和方法。

Periodontal ligament cells(PDLCs)are common cells in periodontal tissues,and they play important roles in maintaining the morphological and functional integrity,force distribution,and homeostasis protection of periodontal tissues.PDLCs are a kind of mechano-sensory cells that can convert mechanical force signals into biological signals,which can regulate the biological behaviors of the downstream cells.Osteoclasts(OCs)are the main functional cells during root resorption,and their viability and quantity are regulated by PDLCs.This paper reviews the research progress on how PDLCs regulate OCs under various mechanical stimulation,and aims to provide new ideas and methods for the prevention and treatment of root resorption.