椎旁肌改变与年龄及椎间盘退变程度的关系

The relationship between paravertebral muscle changes with age and the degree of intervertebral disc degeneration

目的分析椎旁肌的退行性改变与年龄及椎间盘退变程度的关系。方法回顾分析140例腰椎间盘突出症患者的影像资料,使用ImageJ软件测量患者MRI影像上L4~S1层面椎间盘及同层面椎旁肌横截面积,并计算功能性相对椎旁肌横截面积;同层面不同腰椎间盘退变程度间、各年龄组间的功能性相对椎旁肌横截面积的差异用单因素方差分析进行比较;同层面椎间盘退变程度及年龄与功能性相对椎旁肌横截面积的相关性用Spearman相关性分析进行研究;采用多因素线性回归研究功能性相对椎旁肌横截面积的影响因素。结果L5/S1、L4/L5层面上,腰椎间盘的不同退变程度间、各年龄组间的功能性相对椎旁肌横截面积的差异均存在统计学意义,腰椎间盘退变程度及年龄与同层面的功能性相对椎旁肌横截面积均存在负相关(P<0.001),年龄、腰椎间盘退变程度是功能性相对椎旁肌横截面积的影响因素。结论椎旁肌退变与年龄和椎间盘的退变有关。

Objective To analyze the relationship between degenerative changes of paravertebral muscles with age and the degree of intervertebral disc degeneration.Methods The imaging data of 140 patients with lumbar disc herniation(LDH)were retrospectively analyzed.ImageJ software was used to measure the L4~S1 intervertebral disc and the cross-sectional areas of paravertebral muscles on MRI images of patients,and the cross-sectional area of functional relative paravertebral muscles was calculated.One-way analysis of variance was used to compare the differences in cross-sectional area of functional relative paravertebral muscles among different degrees of LDH at the same level and among different age groups.Spearman correlation analysis was employed to study the correlation between the degree of intervertebral disc degeneration,age and functional relative paravertebral muscle cross-sectional area.Multifactor linear regression was used to study the factors influencing functional relative paravertebral muscle cross-sectional area.Results At the L5/S1 and L4/L5 levels,there were statistically significant differences in functional relative paravertebral muscle cross-sectional area among different degrees of lumbar disc degeneration and different age groups.The degree of intervertebral disc degeneration and age were negatively correlated with the functional relative paravertebral muscle cross-sectional area at the same level(P<0.001).Age and degree of intervertebral disc degeneration were factors influencing functional relative paravertebral muscle cross-sectional area.Conclusion Paravertebral muscle degeneration is associated with age and intervertebral disc degeneration.