摘要
临床上诊断为肾小管间质性肾炎-葡萄膜炎(tubulointerstitial nephritis and uveitis,TINU)综合征合并范科尼综合征(Fanconi syndrome)的病例较为罕见。该文报道1例47岁女性患者以低钾血症、低磷血症、低尿酸血症、肾脏损害为首发症状,随后出现葡萄膜炎的TINU综合征病例。血清学检测表明该患者同时符合范科尼综合征的诊断标准。肾组织病理证实为肾小管-间质损伤,表现为间质性肾炎伴急性肾小管损伤。眼科检查证实存在右眼虹膜炎。排除其他原发病,该患者诊断为合并范科尼综合征的TINU综合征。给予糖皮质激素治疗后,患者眼部症状、肾功能损害及电解质紊乱等显著改善。
The clinical diagnosis of tubulointerstitial nephritis and uveitis (TINU) syndrome combined with Fanconi syndrome is relatively rare. The paper reports a 47-year-old female patient of TINU syndrome with hypokalemia, hypophosphatemia, hypouricemia and renal impairment as initial symptoms followed by uveitis. Serological tests showed that the patient also met the diagnostic criteria of Fanconi syndrome. Renal tissue pathology confirmed tubular interstitial injury, manifested as interstitial nephritis with acute tubular injury. Ophthalmic examination confirmed iritis in the right eye. After excluding other primary diseases, the patient was diagnosed as TINU syndrome with Fanconi syndrome. After glucocorticoid therapy, ocular symptoms, renal impairment and electrolyte disturbance were significantly improved.
作者
胥莹
张鑫钰
王庆莲
甄军晖
刘翔
Xu Ying;Zhang Xinyu;Wang Qinglian;Zhen Junhui;Liu Xiang(Department of Nephrology,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,China;Department of Nephrology,Shandong Provincial Hospital,Shandong University,Jinan 250021,China;Department of Pathology,School of Basic Medical Sciences,Shandong University,Jinan 250012,China)
出处
《中华肾脏病杂志》
CAS
CSCD
北大核心
2024年第1期56-60,共5页
Chinese Journal of Nephrology
基金
山东省自然科学基金项目(ZR2020MH079)。