α1酸性糖蛋白在肺部疾病及不同系统疾病中的作用及新进展

Role and new progress of AGP in pulmonary diseases and different systems diseases

α1酸性糖蛋白(alpha1-acid glycoprotein,AGP),又称口腔黏液蛋白(oral mucus protein,ORM),是一种急性期阳性蛋白。AGP具有多种生物活性,如转运药物、调节免疫、维持毛细血管屏障、调节脂质代谢等。AGP主要存在于肝细胞中,其他组织细胞,如脂肪组织、脑组织、内皮细胞和免疫细胞等也有表达AGP。本文主要综述AGP在肺部疾病的应用情况,和在不同系统疾病中的作用、意义及相关新进展。

Alpha1-acid glycoprotein(AGP),also known as oral mucus protein(ORM),is an acute phase positive protein.AGPs have various biological activities,such as drug transport,immune regulation,maintenance of capillary barrier,regulation of lipid metabolism,etc.AGP mainly exists in liver cells,but it is also expressed in other tissue cells,such as adipose tissue,brain tissue,endothelial cells and immune cells.This article mainly reviews the application of AGP in pulmonary diseases,and the role,significance and related new developments in different systemic diseases.