基于微环境调控的脊髓损伤修复策略及相关研究进展

Strategies for spinal cord injury repair based on microenvironmental regulation and relevant research progress

脊髓损伤(spine cord injury,SCI)后,损伤部位会发生出血、炎症和瘢痕形成,脊髓微环境平衡遭到破坏,微环境中有益因子下调,有害因子上调,这些失衡不仅严重损害了神经再生,而且对脊髓功能恢复产生不良影响。为了促进再生,研究者们最近开始关注SCI产生的复杂微环境的调控策略。因此,重建合适的微环境可能是修复脊髓损伤的一种潜在治疗方案。本文将针对近年来利用不同策略调节SCI产生的不同微环境以促进SCI修复的研究进行综述,以期为SCI的研究提供相应帮助。

After spinal cord injury(SCI),bleeding,inflammation and scar formation occur at the injured site.The balance of spinal cord microenvironment is broken up,including the downregulated beneficial factors and upregulated harmful factors.The imbalanced spinal cord microenvironment not only seriously impairs nerve regeneration,but also poses adverse effects on the recovery of spinal cord function.To promote the regeneration,researchers have recently concerned the regulatory strategies of the complex microenvironment generated by SCI.Therefore,reconstructing an appropriate microenvironment may be a potential therapeutic option for SCI repair.This article reviews the recent studies on the use of different strategies to regulate the different microenvironment generated by SCI to promote SCI repair,thus providing the corresponding help for the research.