全麻导致围术期神经认知障碍血清学诊断指标研究进展

Research progress on the possible mechanisms and serum biomarkers of perioperative neurocognitive disorders caused by general anesthesia

全身麻醉在临床诊疗中的比重逐年增高,而围术期神经认知障碍(PND)是全身麻醉常见并发症之一,且具有严重危害,是目前国际领域研究的热点及难点问题。近年来,全身麻醉导致PND的血清相关标志物研究有了新突破。本文对近年全身麻醉导致PND发生相关血清标志物研究进展进行综述,以期为PND防治及评估提供新思路,为提高临床麻醉安全性及患者生活质量提供理论依据。

The prominence of general anesthesia in clinical diagnosis and treatment is growing annually.Perioperative neurocognitive disorders(PND)represent one of the common complications of general anesthesia,posing serious hazards and currently being a hot topic and a challenging problem in international research.Recently,general anesthesia has led to a new breakthrough in the study of PND serum-related markers.Therefore,this article reviews recent progress toward understanding related serum biomarkers of PND caused by general anesthesia.This provides new perspectives for PND prevention,evaluation and furnishes theoretical grounds for enhancing the safety of clinical anesthesia and the quality of life for patients.