多巴丝肼联合普拉克索治疗帕金森病的临床效果

Clinical Effect of Levodopa and Benserazide Hydrochloride Combined with Pramipexole in the Treatment of Parkinson's Disease

目的:分析多巴丝肼联合普拉克索治疗帕金森病的效果。方法:选取2020年5月—2022年4月如东县中医院收治的帕金森病患者86例为研究对象,以随机数字表法分为对照组和研究组,各43例。对照组采用多巴丝肼治疗,研究组在对照组基础上实施普拉克索治疗。比较两组帕金森综合评分量表(UPDRS)评分、治疗效果、不良反应发生率。结果:治疗前,两组UPDRS各维度评分及总分比较,差异无统计学意义(P>0.05);治疗后,两组UPDRS各维度评分及总分均降低,且研究组低于对照组,差异有统计学意义(P<0.05);研究组治疗效果总有效率高于对照组,差异有统计学意义(P=0.024);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:多巴丝肼联合普拉克索治疗帕金森病的效果显著,可有效改善患者临床症状,且不会增加不良反应,安全性高。

Objective:To analyze the effect of levodopa and benserazide hydrochloride combined with pramipexole in the treatment of Parkinson's disease.Methods:A total of eighty-six patients with Parkinson's disease admitted to Nantong Rudong County Hospital of Traditional Chinese Medicine from May 2020 to April 2022 were selected as the study objects,and were divided into control group and study group by random number table method,with forty-three cases in each group.The control group was treated with levodopa and benserazide hydrochloride,and the study group was treated with pramipexole on the basis of the control group.The score of Unified-Parkinson Disease Rating Scale(UPDRS),treatment effect and incidence of adverse reactions were compared between the two groups.Results:Before treatment,there was no significant difference in each dimension and total scores of UPDRS between the two groups(P>0.05);after treatment,the each dimension and total scores of UPDRS of both groups were decreased,and the study group was lower than the control group,the difference was statistically significant(P<0.05);the total effective rate of treatment effect of the study group was higher than that of the control group,and the difference was statistically significant(P=0.024);there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The combination of levodopa and benserazide hydrochloride and pramipexole has a significant effect in the treatment of Parkinson's disease,which can effectively improve the clinical symptoms of patients,and does not increase adverse reactions,and has high safety.