不同剂量丁苯酞对急性脑梗死患者血液流变学及脑血管储备功能的影响

Effects of Different Doses of Butylphthalein on Hemorheology and Cerebral Vascular Reserve Function in Patientswith Acute Cerebral Infarction

目的:探讨不同剂量丁苯酞对急性脑梗死(ACI)患者血液流变学及脑血管储备功能的影响。方法:选取2019年10月—2021年10月黄梅县人民医院收治的ACI患者160例作为研究对象,按简单随机方法分为低剂量组和高剂量组,各80例。两组患者均进行常规治疗,低剂量组给予丁苯酞100 mL/d,高剂量组给予丁苯酞200 mL/d。比较两组患者临床疗效、治疗前后血液流变学及脑血管储备功能、不良反应发生率。结果:高剂量组治疗总有效率高于低剂量组,差异有统计学意义(P=0.043);治疗后,两组红细胞压积、红细胞沉降率、血浆黏度、纤维蛋白原均下降,且高剂量组低于低剂量组,差异有统计学意义(P<0.05);治疗后,两组脑血管储备、脑动脉平均血流量增加值均升高,血流灌注指数均降低,且高剂量组各项指标均优于低剂量组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:高剂量丁苯酞(200 mL/d)治疗ACI患者可获得较好的效果,可改善血液流变学指标,提升脑血管储备功能,安全性较高。

Objective:To investigate the effects of different doses of butylphthalein on hemorheology and cerebral vascular reserve function in patients with acute cerebral infarction(ACI).Methods:A total of one hundred and sixty ACI patients admitted to Huanggang Huangmei County People's Hospital from October 2019 to October 2021 were selected as the study objects,and were divided into low-dose group and high-dose group according to a simple random method,with eighty cases in each group.Both groups received conventional treatment,low-dose group was given 100 mL/d,high-dose group was given 200 mL/d.The clinical efficacy,hemorheology and cerebrovascular reserve function before and after treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of high-dose group was higher than that of low-dose group,and the difference was statistically significant(P=0.043);After treatment,hematocrit,erythrocyte sedimentation rate,plas-ma viscosity and fibrinogen were all decreased in both groups,and the high-dose group was lower than the low-dose group,with statistical significance(P<0.05);After treatment,cerebrovascular reserve and average cerebral artery blood flow increased,and blood perfusion index decreased in both groups,and all indexes in the high-dose group were better than those in the low-dose group,with statistical significance(P<0.05);There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:High-dose butylphthalein(200 mL/d)can achieve good results in the treatment of ACI pa-tients,which can improve hemorheology indexes and enhance cerebrovascular reserve function,with high safety.