土木香内酯联合运动改善认知功能的影响

Effect of Alantolactone Combined with Exercise on Cognitive Function Improvement

本研究探究了土木香根活性成分——土木香内酯(alantolactone,ALA)结合运动对高脂饮食(HFD)诱导的大鼠认知障碍的影响。本研究通过HFD饲料建立大鼠认知障碍模型,随后将其分为七组进行不同干预。其中,E组和E+H-ALA组进行了运动训练,而L-ALA组、M-ALA组和H-ALA组则分别给予不同剂量的土木香内酯灌胃治疗。E+H-ALA组在给药后进行运动。经过6周的干预,结果显示E+H-ALA组大鼠在Morris水迷宫测试中的表现明显优于E组和H-ALA组。此外,该组海马神经元形态、氧化应激指标及炎症相关指标均得到显著改善。本研究为土木香内酯结合运动对于HFD诱导的认知障碍的疗效提供了科学证据,其作用机制可能与抗氧化、抗炎及调整脂代谢基因转录紊乱有关。

This study investigated the effects of the active component from the Tumuxiang(Inula helenium)root,known as alantolactone(ALA),in combination with exercise on cognitive impairments induced by a high-fat diet(HFD)in rats.In the research,a rat model of cognitive impairment was established using HFD.Subsequently,the rats were divided into seven groups for different interventions.Specifically,the E group and E+H-ALA group underwent exercise training,while the L-ALA group,M-ALA group,and H-ALA group received gastric administration of alantolactone at different dosages.The E+H-ALA group exercised post-administration.After a 6-week intervention,results revealed that the E+H-ALA group exhibited superior performance in the Morris water maze test compared to the E group and H-ALA group.Additionally,significant improvements were observed in the hippocampal neuronal morphology,oxidative stress markers,and inflammation-related indicators in this group.This study offers scientific evidence for the therapeutic efficacy of alantolactone combined with exercise on HFD-induced cognitive impairments,suggesting that its mechanism of action might be related to antioxidant properties,anti-inflammatory effects,and regulation of lipid metabolism gene transcriptional disorder.