肾脏超声联合血清学指标对早期糖尿病肾病的诊断价值

The value of renal ultrasound combined with serological indicators in the diagnosis of early diabetes nephropathy

目的:探讨肾脏超声联合血清同型半胱氨酸(Hcy)、胱抑素C(Cys C)、β2微球蛋白(β2-MG)诊断早期糖尿病肾病(DN)的价值。方法:选取早期DN患者(DN组)148例、单纯糖尿病患者(DM组)125例,健康体检者(对照组)130例。结果:DN组肾动脉收缩期峰值流速均低于DM组和对照组,阻力指数均高于DM组和对照组(P<0.05)。DN组Hcy、Cys C、β2-MG均高于DM组和对照组(P<0.05)。肾脏超声联合血清Hcy、Cys C、β2-MG诊断早期DN的AUC为0.931。结论:肾脏超声联合血清学指标对早期DN具有较高的诊断效能。

Objective:To investigate the value of renal ultrasound combined with homocysteine(Hcy),Cystatin C(Cys C)andβ2-microglobulin(β2-MG)in the diagnosis of early diabetic nephropathy(DN).Methods:148 patients with early DN(DN group),125 patients with simple diabetes mellitus(DM group)and 130 healthy people(control group)were selected.All subjects underwent renal ultrasound,recording the peak systolic flow velocity(PSV)and resistance index(RI)of the master renal arteries(MRA)and interlobar renal arteries(IRA),Compare serum Hcy,Cys C,β2-MG levels,Analyze the diagnostic efficacy of renal ultrasound and Hcy,Cys C,β2-MG for early DN.Results:The PSV(MRA)and PSV(IRA)of DN group were lower than those of DM group and control group(P<0.05),the RI(MRA)and RI(IRA)were higher than those of DM group and control group(P<0.05).The levels of serum Hcy,Cys C,β2-MG of DN group were higher than those of DM group and control group(P<0.05).The AUC of renal ultrasound,Hcy,Cys C,β2-MG and its combined in the diagnosis of early DN were 0.787,0.732,0.767,0.750,0.931.Conclusion:Renal ultrasound combined with Hcy,Cys C,β2-MG can improve the diagnostic efficiency of early DN.