宫颈癌患者血清白细胞介素-4和转化生长因子-β_(1)的表达及其与临床预后的相关性

Expression of serum interleukin-4 and transforming growth factor-β_(1) in patients with cervical cancer and its correlation with clinical prognosis

目的探讨宫颈癌(CC)患者血清白细胞介素-4(IL-4)、转化生长因子-β_(1)(TGF-β_(1))的表达及其与临床预后的相关性。方法选取2017年4月至2018年9月赣南医学院第一附属医院收治的84例CC患者作为观察组,另选取同期84例健康女性体检者作为对照组。采集静脉血取血清,测定血清IL-4、TGF-β_(1)水平。比较两组血清IL-4、TGF-β_(1)表达情况,分析血清IL-4、TGF-β_(1)水平与CC患者临床病理特征及临床预后的关系。结果观察组血清IL-4、TGF-β_(1)水平菌均高于对照组,差异有统计学意义(P<0.05);不同年龄、病理类型CC患者的血清IL-4、TGF-β_(1)水平比较差异无统计学意义;CC分化程度越低者IL-4、TGF-β_(1)水平越高,有淋巴结转移者IL-4、TGF-β_(1)水平高于无淋巴结转移者,肿瘤直径>4 cm者IL-4、TGF-β_(1)水平高于≤4 cm者,有复发转移者IL-4、TGF-β_(1)水平高于无复发转移者,且IL-4、TGF-β_(1)水平随着国际妇产科联盟(FIGO)分期增高而逐渐升高,差异有统计学意义(P<0.05);血清IL-4、TGF-β_(1)水平与分化程度呈负相关(r<0,P<0.05),与FIGO分期、淋巴结转移、肿瘤直径、复发转移呈正相关(r>0,P<0.05)。结论CC患者血清IL-4、TGF-β_(1)水平异常增高,其水平高低与病情严重程度和临床预后密切相关。

Objective To investigate the expressions of serum interleukin-4(IL-4)and transforming growth factor-β_(1)(TGF-β_(1))in patients with cervical cancer(CC)and its correlation with clinical prognosis.Methods 84 patients with CC admitted to the First Affiliated Hospital of Gannan Medical College from April 2017 to September 2018 were selected as the observation group,and 84 healthy female physical examiners in the same time were selected as the control group.The venous blood was collected to obtain serum,and the levels of serum IL-4 and TGF-β_(1) were determined,the expressions of serum IL-4 and TGF-β_(1) in the two groups were compared,and the relationship between the levels of serum IL-4 and TGF-β_(1) and the clinicopathological characteristics and clinical prognosis of CC patients were analyzed.Results Serum levels of IL-4 and TGF-β_(1) in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).There were no significant difference in serum levels of IL-4 and TGF-β_(1) in CC patients with different ages and pathological types,the lower the degree of CC differentiation,the higher the levels of IL-4 and TGF-β_(1),the levels of IL-4 and TGF-β_(1) in patients with lymph node metastasis were higher than those without lymph node metastasis,the levels of IL-4 and TGF-β_(1) in patients with tumor diameter>4 cm were higher than tumor diameter≤4 cm,the levels of IL-4 and TGF-β_(1) in patients with recurrence and metastasis were higher than those without recurrence and metastasis,the levels of IL-4 and TGF-β_(1) increased gradually with the increasing stage of FIGO,and the differences were statistically significant(P<0.05).Serum levels of IL-4 and TGF-β_(1) were negatively correlated with the degree of differentiation(r<0,P<0.05),and which were positively correlated with FIGO stage,lymph node metastasis,tumor diameter,recurrence and metastasis(r>0,P<0.05).Conclusion The levels of serum IL-4 and TGF-β_(1) in CC patients are abnormally increased,and their levels are closely related to the severity of the disease and clinical prognosis.