摘要
阿尔茨海默病(Alzheimer’s Disease,AD)是一种以进行性认知功能障碍和记忆减退为主要特征的神经退行性疾病,Tau蛋白过度磷酸化是该病的主要发病机制之一。Tau蛋白是主要分布于中枢神经系统神经元轴突的微管相关蛋白,其过度磷酸化则丧失与微管结合的能力,造成微管解聚、轴突转运障碍,形成Tau聚集体,进而引起神经细胞的凋亡,导致AD的发生。研究表明中医药可以通过多通路、多靶点调控Tau蛋白磷酸化来干预AD。主要以Tau蛋白磷酸化为切入点,对干预AD中医药的种类和作用机制进行总结,以期为中医药防治AD的研究提供参考。
Alzheimer's Disease(AD)is a kind of neurodegenerative disease characterized by progressive cognitive impairment and memory impairment.Hyperphosphorylation of Tau protein is one of the main pathogenesis of the disease.Tau protein is a microtubule-associated protein mainly distributed in the axons of neurons in the central nervous system.Its hyperphosphorylation loses the ability to bind to microtubules,resulting in microtubule depolymerization,axonal transport disorders and the formation of Tau aggregation,which leads to neuronal apoptosis and the occurrence of AD.In recent years,studies have shown that traditional Chinese medicine can interfere with AD through multi-pathway and multi-target regulation of Tau protein phosphorylation.Based on the phosphorylation of Tau protein,this paper summarized the intervention of traditional Chinese medicine on AD,in order to provide reference for the prevention and treatment of AD.
作者
李昱辰
赵伟田
李灿委
尹爱武
范孟然
巫秀美
杨自忠
张成桂
高鹏飞
LI Yuchen;ZHAO Weitian;LI Canwei;YIN Aiwu;FAN Mengran;WU Xiumei;YANG Zizhong;ZHANG Chenggui;GAO Pengfei(College of Pharmacy,Dali University,Dali 671000,Yunnan,China;Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D,Dali University,Dali 671000,Yunnan,China;National Joint Engineering Research Center for The Development of Medicinal Special Insects,Dali University,Dali 671000,Yunnan,China;Dali Prefectural Hospital of Traditional Chinese Medicine,Dali 671099,Yunnan,China;College of Public Health,Dali University,Dali 671000,Yunnan,China;Xiangtan Medicine and Health Vocational College,Xiangtan 411104,Hunan,China)
出处
《中华中医药学刊》
CAS
北大核心
2024年第1期161-165,共5页
Chinese Archives of Traditional Chinese Medicine
基金
国家自然科学基金项目(81260676,82160798,81960712)
中国国家留学基金项目(201708535007)
云南省重大科技计划专项(202002AA100007)。
关键词
阿尔茨海默病
TAU蛋白
中医药
干预
Alzheimer's disease
Tau protein
traditional Chinese medicine
treatment