淫羊藿苷对消化系统肿瘤作用及其机制研究进展

Research Progress on Effects oof lcariin on Digestive System Tumors and Its Mechanism

消化道肿瘤预后差且缺乏有效治疗药物,是导致人类死亡的主要原因之一。淫羊藿(黄檗科)作为补肾壮阳中药用药历史悠久,现代研究表明淫羊藿及其主要活性成分淫羊藿苷(Icaritin,ICA)具有多途径、多靶点的抗肿瘤特性,是有广泛应用前景的抗消化道肿瘤药物,其成药阿可拉定已在肝癌、宫颈癌患者中显示出良好疗效。通过梳理淫羊藿苷调节肿瘤细胞周期,抑制肿瘤细胞增殖和迁徙,调控肿瘤免疫等机制,综述近年来淫羊藿苷在消化系统肿瘤中的研究进展,以期加快淫羊藿苷药理作用分子机制的探索和发现,为临床新药研发提供参考依据。

The poor prognosis and lack of effective drugs of digestive tract tumors is one of the main causes of human death.Yinyanghuo(Epimedii Folium)(Berberidaceae)has a long history as a traditional Chinese medicine for tonifying kidney and strengthening Yang.Modern studies have shown that Yinyanghuo(Epimedii Folium)and its main active component Icaritin(ICA)have multi-pathway and multi-target anti-tumor properties,and are promising anti-gastrointestinal cancer drugs.Acoradine,its patent drug,has shown good efficacy in patients with liver cancer and cervcal cancer.This article reviewed the research progress of ICA in digestive system tumors in recent years by reviewing the mechanisms of ICA regulating tumor cell cycle,inhibiting tumor cell proliferation and migration and regulating tumor immunity so as to accelerate the exploration and discovery of the molecular mechanisms of the pharmacological effects of ICA and provide a reference basis for clinical new drug development.