肝特异性对比剂对肝脏局灶性病变磁共振成像诊断研究进展

Research Progress in Liver Specific Contrast Agents for MRI Diagnosis of Focal Liver Lesions

磁共振成像是检测和表征肝脏局灶性病变的金标准,Gd-EOB-DTPA是一种肝特异性磁共振对比剂,因具有细胞内外双重对比剂效应,对肝脏局灶性病变具有较高的定性诊断准确率,且能够提供肝细胞功能方面的信息。文章首先介绍了肝特异性对比剂的作用机制,并结合既往文献对其在肝脏局灶性病变的磁共振成像诊断研究进展进行综述,旨在提高临床医师对肝特异性对比剂诊断肝脏局灶性病变应用价值的认识。

Magnetic resonance imaging(MRI)is the gold standard for detecting and characterizing focal liver lesions,while Gd-EOB-DTPA is a liver specific magnetic resonance contrast agent.Due to its dual intracellular and extracellular contrast effects,it has a high qualitative diagnostic accuracy for focal liver lesions and can provide information on liver cell function.This article first introduces the mechanism of action of liver specific contrast agents,and reviews their research progress in MRI diagnosis of focal liver lesions in combination with previous literature.The aim is to improve clinical physicians’understanding of the application value of liver specific contrast agents in the diagnosis of focal liver lesions.