超声内镜应用于早期贲门癌及癌前病变治疗中的有效性及安全性探讨

Discussion on the Effectiveness and Safety of Endoscopic Ultrasound in the Treatment of Early Cardiac Cancer and Precancerous Lesions

目的:探讨超声内镜应用于早期贲门癌及癌前病变治疗中的有效性及安全性。方法:选择98例早期贲门癌及癌前病变患者,均接受超声内镜检查及内镜下黏膜剥离术,回顾性分析有效性及安全性。结果:①超声内镜检查结果提示贲门黏膜均发生病变。病理检查共确定98处病灶,平均肿瘤直径(12.87±2.30)mm。后壁为多发位置,大体类型以0-Ⅱc型、0-Ⅱa+Ⅱc型为主;浸润深度:SM151处,SM247处;浸润模式以INFa为主;②98处病灶中治愈性切除率44.90%,不良事件发生率3.06%;③治愈性切除组与非治愈性切除组在大体类型、浸润深度、浸润模式构成方面对比,P<0.05。结论:超声内镜应用于早期贲门癌及癌前病变治疗中有效性及安全性较高。

Objective:To explore the effectiveness and safety of endoscopic ultrasound in the treatment of early cardiac cancer and precancerous lesions.Methods:98 patients with early-stage cardia cancer and precancerous lesions were taken as an example.All patients underwent endoscopic ultrasonography and endoscopic mucosal dissection,and the effectiveness and safety were retrospectively analyzed.Results:①The results of endoscopic ultrasonography showed that all cardiac mucosa had lesions.A total of 98 lesions were identified by pathological examination,with an average tumor diameter of(12.87±2.30)mm.The posterior wall has multiple locations,and the general types are mainly type 0-Ⅱc and type 0-Ⅱa+Ⅱc;Depth of infiltration:51 locations in SM1 and 47 locations in SM2;The main infiltration pattern is INFa.②The curative resection rate among 98 lesions was 44.90%,and the adverse event rate was 3.06%.③The comparison between the curative resection group and the non-curative resection group in terms of general type,invasion depth,and invasion pattern composition was P<0.05.Conclusion:Endoscopic ultrasound is highly effective and safe in the treatment of early cardiac cancer and precancerous lesions.