青少年抑郁障碍患者血清FGF2和BDNF表达与病情程度及CI的关系

目的探讨青少年抑郁障碍患者血清成纤维细胞生长因子2(FGF2)和脑源性神经生长因子(BDNF)表达与病情程度及认知功能障碍(CI)的关系。方法选取2021年1月至2022年8月在本院治疗的88例青少年抑郁障碍患者(观察组)为研究对象,根据病情程度将其分为轻度组、中度组、重度组,根据是否发生CI将其分为非CI组和CI组,另选取同期入院体检的88例健康志愿者作为对照组。采用酶联免疫吸附法(ELISA)检测血清FGF2、BDNF水平。结果重度组血清FGF2、BDNF水平低于中度组和轻度组,重度组HAMD-17评分高于中度组和轻度组(P<0.05)。血清FGF2、BDNF二者联合诊断青少年发生重度抑郁障碍、发生CI均优于单独诊断(P<0.05)。结论血清FGF2、BDNF水平随青少年抑郁障碍患者疾病严重程度加重而降低,且与CI发生相关,可能作为病情程度和CI发生的预测指标。

Objective To investigate the relationship between the expression of serum fibroblast growth factor 2(FGF2)and brain derived nerve growth factor(BDNF)in adolescent depressive disorder and the severity of the disease and cognitive impairment(CI).Methods A total of 88 adolescent depressive disorder patients(study group)who were treated in our hospital from January 2021 to August 2022 were collected as the study subjects,according to the severity of the disease,they were grouped into the mild group,the moderate group,and the severe group,according to whether CI occurred,they were grouped into the non CI group and the CI group,in addition,88 healthy volunteers without neurological diseases and with normal cognitive function who underwent physical examination were collected as the control group.Serum levels of FGF2 and BDNF were detected by enzyme linked immunosorbent assay(ELISA).Results The levels of serum FGF2 and BDNF in the severe group were lower than those in the moderate group and mild group,and the Hamilton Depression Rating Scale 17-item(HAMD-17)score was higher than those in the moderate group and mild group(P<0.05).Combined diagnosis of serum FGF2 and BDNF in adolescents with severe depressive disorder and CI was better than that of single diagnosis(P<0.05).Conclusion The serum levels of FGF2 and BDNF decrease with the increase of disease severity in adolescent depressive disorder patients,they are related to the occurrence of CI and may be used as a predictive indicators of the severity of disease and the occurrence of CI.