骨肉瘤细胞生长的自分泌和旁分泌调节的研究进展

Research progress on autocrine and paracrine regulation of osteosarcoma cell growth

骨肉瘤(osteosarcoma,OS)为骨组织中最常见的恶性肿瘤之一,其具体发生机制目前尚未完全明确。研究证明,OS细胞在肿瘤发展阶段表达不同的细胞因子(cytokine,CK)及其受体,通过自分泌和旁分泌作用使其能够自主生长并赋予转移能力。参与作用的CK主要包括胰岛素样生长因子-1、转化生长因子-β、趋化因子5、白细胞介素-8,它们可调节肿瘤微环境,有利于肿瘤的生长、侵袭和转移。本文对CK的作用、作用方式及其与OS细胞的生物学相关性作一综述,以期为OS的临床治疗提供有效的新标志物和治疗靶点。

Osteosarcoma(OS)is one of the most common malignant tumors in bone tissue,and its specific mechanism is not yet fully clear.Studies have shown that OS cells express different cytokines(CKs)and their receptors in the development stage of tumors,and enable them to grow autonomously and confer metastatic ability through autocrine and paracrine effects.In this regard,the most important CKs mainly includes insulin-like growth factor-1,transforming growth factor-β,chemokine 5 and interleukin-8,which can regulate the tumor microenvironment that is conducive to tumor growth,invasion and metastasis.This review summarizes the role and mode of action of CKs and their biological relevance to OS cells,hoping to provide effective new markers and therapeutic targets for clinical treatment of OS.