从“神机”与“气立”探讨孤独症谱系障碍的发病机制

Discussion on Disease Mechanism of Autism Spectrum Disorders from the Concepts of“Vital Activity”and“Qi Configuration”

从“神机”“气立”角度探讨孤独症谱系障碍(ASD)的发病机制,认为“神机”代表人体内部的调控机制,“气立”则代表人体与外部环境的交流和适应能力。遗传因素异常导致ASD患儿“神机化灭”,ASD易感性的增加;环境因素失稳导致ASD“气立孤危”,在遗传易感性的基础上触发和加重ASD的表现。此外,表观遗传机制也在ASD的发病中起到重要作用,神机失衡、气立失调则脏腑气化失司,机体表现出以五窍为载体的失常症状。提出治疗ASD需使“神机”“气立”相辅相成,加速患儿的康复。

This paper explored the disease mechanism of autism spectrum disorders(ASD)from the perspec⁃tives of“vital activity”and“qi configuration”,and it is believed that“vital activity”represents the internal regulatory mechanisms of the human body,while“qi configuration”represents the ability of the body to communicate and adapt to the external environment.Abnormal genetic factors lead to the extinction of vital activity in children with ASD,resulting in increased susceptibility to ASD.Environmental instability leads to the solitary qi configuration in ASD,triggering and exacerbating the manifestations of ASD on the basis of genetic susceptibility.In addition,epigenetic mechanisms also play an important role in the pathogenesis of ASD.Imbalances in vital activity and disruptions in qi configuration result in failure in qi transformation of zang-fu organs,with abnormal symptoms manifested through the five orifices.It is proposed that the treatment of ASD should aim to achieve a harmonious interaction between“vital activity”and“qi configuration”to accelerate the recovery of affected children.