肉芽肿性小叶性乳腺炎复发率及危险因素的系统评价

Recurrence rates and risk factors for granulomatous lobular mastitis:a systematic review

目的:系统评价肉芽肿性小叶性乳腺炎(GLM)的复发情况。方法:计算机检索中国知网(CNKI)、万方数据库(WanFang Database)、中国生物医学文献数据库(CBM)、维普数据库(VIP)、PubMed、Web of Science、EMbase,搜集有关GLM复发因素相关的研究,检索时限为建库至2023年5月16日。结果:最终纳入9篇文献,涉及1741例GLM病人。Meta分析结果显示:GLM复发率为16%[95%CI(12%,21%)],影响因素分析显示,棒状杆菌感染[OR=4.80,95%CI(1.76,13.09),P<0.01]、吸烟[OR=11.01,95%CI(1.14,106.78),P<0.05]等是GLM复发的独立危险因素。结论:现有证据表明,GLM复发率较高,且受棒状杆菌感染和吸烟等因素的影响,受纳入研究数量的限制,研究结果尚待更多高质量研究予以验证。

Objective:To systematically evaluate the recurrence of granulomatous lobular mastitis(GLM).Methods:Studies on influencing factors of GLM recurrence were retrieved from CNKI,WanFang Database,CBM,VIP,PubMed,Web of Science,and EMbase,from the establishment of the database to May 16,2023.Results:A total of 9 articles were included,involving 1741 GLM patients.Meta-analysis results showed that the recurrence rate of GLM was(16%,95%CI 12%-21%).The analysis of influencing factors showed that Corynebacterium infection(OR=4.80,95%CI 1.76-13.09,P<0.01),smoking(OR=11.01,95%CI 1.14-106.78,P<0.05),etc.were independent risk factors for GLM recurrence.Conclusions:Existing evidence shows that the recurrence rate of GLM is high and is affected by factors such as Corynebacterium infection and smoking.Due to the limited number of included studies,the research results need to be verified by more high-quality studies.