醒脑开窍针刺联合柴胡加龙骨牡蛎汤治疗卒中后癫痫的效果观察

ffObservation on the effect of Xingnaokaiqiao acupuncture combined with Chaihu-jia-Longgu-Muli-Decoction in the treatment of post-stroke epilepsy

目的探讨醒脑开窍针刺联合柴胡加龙骨牡蛎汤治疗卒中后癫痫的效果。方法选取2021年2月-2022年2月本院收治的168例卒中后癫痫患者为研究对象,利用随机数字表法将其分为观察组和对照组,各84例,对照组采用柴胡加龙骨牡蛎汤治疗,观察组采用醒脑开窍针刺联合柴胡加龙骨牡蛎汤治疗,比较2组患者的中医证候积分、癫痫发作情况、认知功能、血清学指标、治疗效果、不良反应发生情况。结果治疗后,观察组中医证候积分低于对照组(P<0.05);观察组发作频率及发作时间低于对照组(P<0.05);观察组蒙特利尔认知评估量表(Montreal Cognitive Assessment,MoCA)评分及总有效率高于对照组(P<0.05);观察组单核细胞趋化蛋白-1(monocyte chemotactic protein-1,MCP-1)、非对称二甲基精氨酸(ADMA)和神经元特异性烯醇化酶(NSE)水平低于对照组(P<0.05);2组不良反应发生情况差异无统计学意义(χ^(2)=0.525,P=0.469)。结论醒脑开窍针刺联合柴胡加龙骨牡蛎汤治疗能够有效改善患者的中医证候及癫痫发作情况,提高认知功能及治疗效果,降低患者血清学指标,值得推广。

Objective To explore the effect of Xingnaokaiqiao acupuncture combined with Chaihu-jia-Longgu-Muli-Decoction on post-stroke epilepsy.Methods A total of 168 patients with post-stroke epilepsy admitted to Linfen People's Hospital from February 2021 to February 2022 were selected as the research subjects,and they were divided into the observation group and the control group according to random number table method,with 84 cases in each group.The control group was treated with Chaihu-jia-Longgu-Muli-Decoction,while the observation group was treated with Xingnaokaiqiao acupuncture combined with Chaihu-jia-Longgu-Muli-Decoction.The traditional Chinese medicine(TCM)syndrome scores,seizure condition,cognitive function,serological indexes levels,therapeutic effect and occurrence of adverse reactions were compared between two groups.Results After treatment,the TCM symptom score of the observation group was lower than that of the control group(P<0.05).The frequency and duration of seizure in the observation group were lower than those in the control group(P<0.05).Montreal Cognitive Assessment(MoCA)score and total effective rate of the observation group were higher than those of the control group(P<0.05).The levels of monocyte chemotactic protein-1(MCP-1),asymmetric dimethylarginine(ADMA)and neuron specifie enolase(NSE)in the observation group were lower than those in the control group(P<0.05);There was no statistically significant difference in the occurrence of adverse reactions between two groups(χ^(2)=0.525,P=0.469).Conclusion Xingnaokaiqiao acupuncture combined with Chaihu-jia-Longgu-Muli-Decoction can effectively improve the TCM symptoms and epileptic seizure,improve cognitive function and therapeutic effect,and reduce the serological indexes levels of patients,which is worth promoting.