丹酚酸B在帕金森病动物模型中的神经保护作用及临床应用进展

ffNeuroprotective effects and clinical progress of salvianolic acid B in animal models of Parkinson's disease

作为一种逐渐进展的神经系统变性疾病,帕金森病在老年人群体中的发病率较高,主要病理机制为多巴胺神经元丧失、神经纤维缠结的形成、氧化应激和线粒体功能受损、炎症反应和蛋白质代谢异常。丹酚酸B作为一种从丹参中提取的活性成分,其对帕金森病的神经保护作用机制为抗氧化作用、改善线粒体功能、调控神经炎症、抑制细胞凋亡、促进神经元分化与增值和影响肠道菌群。丹酚酸B作为辅助药物与常规治疗药物联合使用,具有增强疗效、减少副作用的功效,其为临床进行帕金森病早期诊断及治疗提供了方法及依据。

As a progressive neurodegenerative disease,Parkinson's disease has a high incidence in the elderly population.The main pathological mechanisms are dopamine neuron loss,neurofibrillary tangles formation,oxidative stress and mitochondrial dysfunction,inflammatory reaction and abnormal protein metabolism.Salvianolic acid B,as an active ingredient extracted from Radix Salviae Miltiorrhizae,has neuroprotective effects on Parkinson's disease through antioxidation,improving mitochondrial function,regulating neuroinflammation,inhibiting apoptosis,promoting neuron differentiation and proliferation,and affecting intestinal flora.Salvianolic acid B,as an auxiliary drug,combined with conventional drugs,has the effect of enhancing curative efficacy and reducing side effects,which provides methods and basis for early diagnosis and treatment of Parkinson's disease in clinical practice.