甘油氧化酯化制备乳酸甲酯的研究进展

Research progress in the preparation of methyl lactate by oxidative esterification of glycerol

乳酸甲酯作为生物质平台化合物,广泛应用于食品、医药等行业。在诸多合成乳酸甲酯的路线中,以甘油为原料,不添加均相碱助剂条件下,在甲醇体系中直接氧化酯化得到乳酸甲酯,再以乳酸甲酯水解得到精乳酸的思路,符合“绿色”可持续发展要求,具有重要的研究价值。本文首先对已报道的甘油氧化酯化制备乳酸甲酯的催化体系进行了综述,总结了所使用催化剂类型,并明确了这类催化体系的作用机理。基于甘油制备乳酸甲酯的反应路线,分别对已报道的甘油氧化制备1,3-二羟基丙酮和1,3-二羟基丙酮制备乳酸甲酯所使用催化体系进行了综述,总结了这两类反应所使用的催化剂类型和作用机理。最后,对甘油氧化酯化制备乳酸甲酯的催化体系未来发展方向进行了展望。

As a biomass platform compound,methyl lactate is widely used in food,medicine and other industries.Among the many synthetic routes of methyl lactate,the idea of using glycerol as raw material and without homogeneous alkali additives,directly oxidize esterification in methanol system to obtain methyl lactic acid,and then obtaining refined lactic acid by hydrolysis is in line with the requirements of“green”sustainable development and has important research value.In this paper,we first review the reported catalytic systems of glycerol,summarize the types of catalysts used,and define the mechanism of action of such catalytic systems.Then,based on the reaction route of glycerol,the reported catalytic systems used for glycerol oxidation to 1,3-dihydroxyl acetone and 1,3-dihydroxyl acetone to methyl lactate are reviewed,respectively,and the types and mechanisms of catalysts used in these two reactions are summarized.Finally,the future direction of catalytic system of glycerol esterification to make methyl lactate is discussed.