蛋白质翻译后修饰之间的互作关系及其协同调控机理

Crosstalk Between Different Post-translational Modifications and Its Regulatory Mechanisms in Plant Growth and Development

蛋白质的翻译后修饰在细胞信号转导过程中起核心调控作用。除了单一翻译后修饰的调控外,细胞中还存在由多个翻译后修饰共同调控一些关键的代谢或信号通路的分子机制。翻译后修饰是蛋白质之间的语言,通过不同修饰之间的相互作用和协同调控,把复杂的信号整合后传递到下游其他蛋白并形成信号网络,最终影响蛋白质的结构、亚细胞定位、相互作用以及生物学功能。本文概述磷酸化、泛素化和类泛素化三类重要的翻译后修饰在植物细胞信号通路中的串扰作用模式及协同调控机制。

Post-translational modifications(PTMs)have key regulatory roles in cell signal transduction networks.In addition to be a single PTM,many proteins undergo the regulation of multiple different types of PTMs,which functions in an orchestrated manner to adapt external or internal environmental cues.Such PTM crosstalk affects protein interactions,stabilities and subcellular localizations,and ultimately acts as a signaling hub to control diverse biological processes.Although PTM crosstalk has been extensively studied in humans and animals,the investigation in plants is just emerging.In this review,we discuss recent advances in crosstalk among three of the most common PTMs in plants,including phosphorylation,ubiquitination,and sumoylation,furthermore we highlight how this crosstalk may be connected to downstream signaling outputs.