急性缺血性卒中血栓特征的研究进展

Research progress on the characteristics of thrombosis in acute ischemic stroke

血栓栓塞和原位血栓形成是缺血性卒中发生的最主要原因,但由于人体血栓组织获取困难,既往关于卒中血栓特征的研究较少。近年来,血管内介入技术的快速发展为研究血栓构成创造了条件。该文从病理学、免疫组织化学、组学、力学、外源性物质5个方面回顾了急性缺血性卒中血栓的构成特点,分析了这些特征在卒中诊断、分类及治疗方案制定中的价值,并探讨了这些特征对急性缺血性卒中患者行机械取栓术后神经功能预后的影响。

Embolism and thrombosis in situ are the major causes of ischemic stroke.However,due to the difficulty in obtaining human thrombus tissue,limited data exist on composition of arterial thrombi in acute ischemic stroke.The rapid development of endovascular procedures has provided new opportunities to study detailed characteristics of thrombi.In this review,we provided a comprehensive overview of the lessons learned by examining stroke thrombus composition after endovascular thrombectomy from five aspects of pathology,histopathology,omics,mechanics,exogenous substances,which may help to understand the value in diagnosis,classification and treatment.The impact on functional outcomes after the acute ischemic stroke with mechanical thrombectomy was also explored.