干扰素刺激基因15抗病毒感染的分子机制

Molecular Mechanism of Interferon-Stimulated Gene 15 Antiviral Infection

干扰素刺激基因15(ISG15)是由病原微生物或干扰素诱导产生的一种大小为15 kDa的泛素样蛋白。在干扰素诱导的数百个干扰素刺激基因中,ISG15是诱导最强烈、最快的ISG蛋白之一。研究表明,ISG15对多种病毒具有抗病毒作用。此外,ISG15在调节宿主损伤、DNA修复,调节信号通路及抗原递呈中也发挥着重要的作用。文章介绍了ISG15的概况,并阐述了近年来ISG15在抗病毒、免疫调节和调节宿主信号通路过程中的作用。

Interferon-stimulated gene 15(ISG15)is a ubiquitin-like protein of approximately 15 kDa induced by pathogenic microorganisms or interferons.Among the hundreds of interferon-stimulated genes induced by interferons,ISG15 is one of the most strongly and fastest induced ISG proteins.Studies have shown that ISG15 has antiviral effects against a variety of viruses.In addition,ISG15 plays an important role in regulating host damage,DNA repair,and regulating signaling pathways and antigen delivery.The article presented an overview of ISG15 and described the role of ISG15 in the process of antiviral,immunomodulation and regulation of host signaling pathways in recent years.