聚己内酯增强β-磷酸三钙复合支架的制备及力学性能

Preparation and Mechanical Properties of Polycaprolactone Enhancementβ-tricalcium Phosphate Composite Scaffold

针对生物陶瓷在大段骨缺损的修复重建中韧性不足的问题,采用数字光处理技术和涂层工艺,制备了集高强度韧性一体化的生物陶瓷β-磷酸三钙/聚己内酯复合支架,并研究了聚己内酯涂层浓度对复合支架抗压抗弯性能和微观形貌的影响。实验结果表明:聚己内酯涂层可有效提高β-磷酸三钙陶瓷支架的力学性能,复合支架的强度和韧性均与聚己内酯涂层浓度呈正相关性;随着聚己内酯涂层浓度的提高,复合支架的可靠性显著提高,涂层效果有明显的改善,但不均匀现象也越明显;结合力学性能和微观形貌评价发现,0.20 g/mL聚己内酯增强β-磷酸三钙复合支架的综合性能最佳。该研究可为制备满足骨生长到骨强化两阶段力学性能要求的复合支架提供参考。

To address the insufficient toughness of bioceramics in the repair and reconstruction of large bone defects,a bioceramicβ-tricalcium phosphate/polycaprolactone composite scaffold with high strength and toughness is fabricated using digital light processing technology and coating techniques.The effects of the concentration of polycaprolactone coating on the compressive and flexural properties and microstructure of the composite scaffold are studied.The results show that polycaprolactone coating effectively improves the mechanical properties of theβ-tricalcium phosphate ceramic scaffold.Both the strength and toughness of the composite scaffold are positively correlated with the concentration of polycaprolactone coating.The reliability of the composite scaffold is improved and coating effectiveness is enhanced significantly with the increase of coating concentration,but unevenness becomes more pronounced.The evaluation of mechanical properties and microstructural morphology shows that the composite scaffold with a polycaprolactone concentration of 0.20 g/mL exhibits the best overall performance.This study lays a foundation for the fabrication of composite scaffolds that meet the mechanical property requirements of both bone growth and bone reinforcement stages.