以急性前庭综合征为首发表现的抗GQ1b抗体综合征1例报告

A case report and literature review of anti-GQ1B antibody syndrome with acute vestibular syndrome as the first manifestation

目的 分析以急性前庭综合征为首发表现的抗GQ1b抗体综合征的临床特点及眼部运动表现。方法 报道1例以急性前庭综合征为首发表现的抗GQ1b抗体综合征患者,并进行相关文献复习。结果 该患者存在自发眼震及凝视诱发眼震,同时有头脉冲试验异常,合并眼肌麻痹。结论 抗GQ1b抗体综合征是一组累及周围和中枢神经系统,以眼肌麻痹、共济失调、意识障碍等为主要表现的自身免疫性谱系疾病。以急性前庭综合征为主要表现的这一组疾病可能是抗GQ1b抗体综合征的一个亚型,可与其他类别重叠。

Objective To analyze the clinical characteristic and ocular motor findings in acute vestibular syndrome(AVS)associated with anti-GQ1b antibodies.Methods A case of anti-GQ1b antibody clinically manifested by acute vestibular syndrome was reported and the relevant literature was reviewed in this study.Results Patients with AVS showed spontaneous nystagmus,gaze-evoked nystagmus,abnormal head-impulse tests and ophthalmoplegia.Conclusion Anti-GQ1B antibody syndrome is a continuous autoimmune disease involving the peripheral and central nervous system,mainly manifested by ocular muscle paralysis,ataxia,and disturbance of consciousness.Vestibular syndrome may constitute a subtype of anti-GQ1b antibody syndrome,and can overlap with other categories.