转录因子p53与脑出血铁死亡的研究进展

Research progress of transcription factor p53 and ferroptosis after intracerebral hemorrhage

脑出血是死亡率最高的脑卒中亚型,占脑血管疾病的35%,具有高致残、致死率。铁死亡是一种铁依赖性非凋亡细胞死亡模式,近年来发现在脑卒中存在铁死亡现象。p53作为一种转录因子,p53表达不足的情况下可以促进铁死亡的发生;此外,通过各种代谢途径p53能够在存在铁死亡诱导剂(如谷胱甘肽过氧化酶4抑制剂或高水平的活性氧)的情况下抑制铁死亡。p53作为典型和非典型铁死亡途径的关键调节因子参与铁死亡的调节。本文就p53与脑出血后铁死亡脑损伤关系的研究进展进行综述。

Cerebral hemorrhage is the stroke subtype with the highest mortality rate,accounting for 35%of cerebrovascular diseases,with high lethality and disability.Ferroptosis is an iron-dependent non-apoptotic cell death mode,and in recent years,it has been found that ferroptosis also occurs in stroke.p53 acts as a transcription factor,and p53 under-expression promotes ferroptosis;moreover,through various metabolic pathways,p53 is able to inhibit ferroptosis in the presence of ferroptosis-inducing agents(such as glutathione peroxidase 4 inhibitors or high levels of reactive oxygen species).The p53 is involved in the regulation of ferroptosis as a key regulator of both typical and atypical ferroptosis pathways.In this paper,the research progress on the relationship between p53 and ferroptosis brain injury after cerebral hemorrhage is summarized as follows.