甲基纤维素基温敏水凝胶在生物医学领域的研究进展

Research progress of methylcellulose-based thermosensitive hydrogels applied in biomedical field

甲基纤维素(MC)是一种半柔性纤维素醚衍生物,其水凝胶温敏可逆,生物相容性良好,功能可调,其应用在生物医学领域备受关注。本文对甲基纤维素温敏水凝胶在生物医学领域的应用进展进行了综述。在对甲基纤维素的凝胶化机制及凝胶化影响因素进行论述的基础上,重点介绍了甲基纤维素基水凝胶在生物医学领域的应用进展,包括在药物递送、再生医学及其他方面等的应用,列表总结了相关领域的成果,为后续研究提供思路和方向。最后,还讨论了甲基纤维素基多功能水凝胶材料的未来发展。

Methylcellulose is a semi-flexible cellulose ether derivative,whose hydrogels are thermosensitive and reversible,with good biocompatibility and adjustable function,and its application has attracted much attention in the biomedical field.In this paper,the application of methylcellulose-based thermo-sensitive hydrogels in biomedical field was reviewed.Based on the mechanism of gelation and influencing factors of methylcellulose,this paper focused on the recent advances in biomedical applications of methylcellulose-based hydrogels,including drug delivery,regenerative medicine,and other related fields.The current achievements in these fields were summarized in the form of lists in this paper to provide ideas and tendencies for future research.Finally,the future development of multifunctional methylcellulose-based hydrogel materials with improved performance was also discussed.