特布他林、孟鲁司特钠联合治疗慢性阻塞性肺疾病急性加重患者的临床效果

Clinical efficacy of combination therapy of terbutaline and montelukast sodium in patients with acute exacerbation of chronic obstructive pulmonary disease

目的:探讨在慢性阻塞性肺疾病急性加重治疗中,特布他林联合孟鲁司特钠治疗效果。方法:选择2022年5月至2023年5月海安市人民医院治疗的患者共90例,随机数字表法分成对照组和观察组,各45例,并分别予常规治疗、联合治疗,比较两组患者肺功能、炎性因子等指标。结果:观察组治疗有效率高于对照组(97.8%vs 86.6%)(χ^(2)=3.980,P=0.001),且观察组治疗后一秒用力呼气容积、用力肺活量和FEV1/FVC分别是(2.79±0.4)L、(2.89±0.78)L、(79.19±7.99),高于对照组[(2.18±0.99)L、(2.18±0.38)L、(60.59±5.90)],差异有统计学意义(均P<0.05)。观察组治疗后动脉血氧分压(arterial partial pressure of oxygen,PaO_(2))和pH水平高于对照组,动脉血二氧化碳分压(arterial partial pressure of carbondioxide,PaCO_(2))水平低于对照组,差异有统计学意义(P<0.05)。观察组治疗后炎症因子指标与单核细胞趋化蛋白1(active monocyte chemotactic protein 1,MCP-1)指标低于对照组,差异有统计学意义(P<0.05)。结论:在慢性阻塞性肺疾病急性加重治疗中,特布他林联合孟鲁司特钠治疗效果明显。

Objective:To investigate the therapeutic effect of terbutaline combined with montelukast sodium in the treatment of acute exacerbation of chronic obstructive pulmonary disease.Methods:A total of 90 patients treated in our hospital from May 2022 to May 2023 were enrolled in this study and randomized into control group and observation group,with 45 in each.The patients in the two groups were treated with routine treatment and combination therapy,respectively.The lung functional indexes,inflammatory factors,and other indicators were compared between the 2 groups.Results:The effective rate of treatment in the observation group was higher than that in the control(97.8%vs 86.6%)(χ^(2)=3.980,P=0.001).After treatment,the forced expiratory volume,forced vital capacity,and FEV1/FVC in the observation group were(2.79±0.4)L,(2.89±0.78)L,and(79.19±7.99)L,respectively,which were higher than those in the control(2.18±0.99)L,(2.18±0.38),and(60.59±5.90)L(P<0.05).The arterial partial pressure of oxygen(PaO_(2))and pH levels in the observation group were higher than those in the control group,while the arterial partial pressure of carbon dioxide(PaCO_(2))levels were lower than those in the control group(P<0.01).The inflammatory cytokine index and monocyte chemotactic protein-1(MCP-1)index in the observation group were obviously lower than those in the control group(P<0.01).Conclusion:In the treatment of acute exacerbation of COPD,the combination of terbutaline and montelukast sodium has a significant therapeutic effect.