药物涂层球囊在经皮冠状动脉介入术治疗冠心病患者中的应用效果

Application effects of drug-coated balloon in patients with coronary heart disease treated by percutaneous coronary intervention

目的:观察药物涂层球囊在经皮冠状动脉介入术(PCI)治疗冠心病患者中的应用效果。方法:回顾性分析2022年4月至2023年4月该院收治的70例行PCI治疗冠心病患者的临床资料,根据治疗方法不同将其分为对照组(n=35)与观察组(n=35)。对照组采用药物洗脱支架治疗,观察组采用药物涂层球囊治疗,比较两组临床疗效、治疗前后心功能指标[左心室收缩分数(LVSF)、左心室射血分数(LVEF)、左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)]水平、不良心血管事件发生率、冠状动脉再狭窄率和心绞痛复发率。结果:观察组治疗总有效率为97.14%(34/35),高于对照组的74.29%(26/35),差异有统计学意义(P<0.05);治疗后,两组LVSF、LVEF水平均高于治疗前,且观察组高于对照组,两组LVEDD、LVESD水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组不良心血管事件发生率为2.86%(1/35),低于对照组的22.86%(8/35),差异有统计学意义(P<0.05);观察组冠状动脉再狭窄率和心绞痛复发率均低于对照组,差异有统计学意义(P<0.05)。结论:药物涂层球囊用于行PCI治疗冠心病患者可提高治疗总有效率,改善心功能指标水平,降低不良心血管事件发生率、冠状动脉再狭窄率和心绞痛复发率,其效果优于药物洗脱支架治疗。

Objective:To observe application effects of drug-coated balloon in patients with coronary heart disease treated by percutaneous coronary intervention(PCI).Methods:The clinical data of 70 patients with coronary heart disease treated by PCI in this hospital from April 2022 to April 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group(n=35)and observation group(n=35).The control group was treated with drug-eluting stent,while the observation group was treated with drug-coated balloon.The clinical efficacy,the cardiac function indexes[left ventricular systolic fraction(LVSF),left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD)]levels before and after the treatment,the incidence of adverse cardiovascular events,the coronary artery restenosis rate,and the recurrence rate of angina pectoris were compared between the two groups.Results:The total effective rate of the observation group was 97.14%(34/35),which was higher than 74.29%(26/35)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of LVSF and LVEF in the two groups were higher than those before the treatment,and those in the observation group were higher than those in the control group;the levels of LVEDD and LVESD in the two groups were lower than those before the treatment,and those in the observation group were lower than those in the control group;and the differences were statistically significant(P<0.05).The incidence of adverse cardiovascular events in the observation group was 2.86%(1/35),which was lower than 22.86%(8/35)in the control group,and the difference was statistically significant(P<0.05).Further,the coronary artery restenosis rate and the recurrence rate of angina pectoris in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusions:The drug-coated balloon in PCI for the patients with coronary heart disease can improve the total effective rate of treatment,improve the levels of cardiac function indicators,and reduce the incidence of adverse cardiovascular events,the coronary restenosis rate and the recurrence rate of angina pectoris.Moreover,it is superior to drug-eluting stent treatment.