甘草酸二铵胶囊联合肌苷片治疗老年药物性肝损伤患者的效果

Effects of Diammonium glycyrrhizinate capsules combined with Inosine tablets in treatment of elderly patients with drug-induced liver injury

目的:观察甘草酸二铵胶囊联合肌苷片治疗老年药物性肝损伤患者的效果。方法:选取2021年1月至2022年1月该院收治的68例老年药物性肝损伤患者进行前瞻性研究,按照随机数字表法将其分为对照组和研究组各34例。对照组予以肌苷片治疗,研究组在对照组基础上联合甘草酸二铵胶囊治疗,两组均连续治疗2个月。比较两组临床疗效,治疗前后肝功能指标[丙氨酸氨基转移酶(ALT)、总胆红素(TBIL)、天门冬氨酸氨基转移酶(AST)、碱性磷酸酶(ALP)]水平、炎性因子[C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平、氧化应激指标[丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)]水平,以及不良反应发生率。结果:研究组治疗总有效率为97.06%(33/34),高于对照组的76.47%(26/34),差异有统计学意义(P<0.05);治疗后,研究组ALT、AST、TBIL、ALP水平均低于对照组,差异有统计学意义(P<0.05);治疗后,研究组CRP、IL-6、TNF-α水平均低于对照组,差异有统计学意义(P<0.05);治疗后,研究组MDA水平低于对照组,SOD、GSH-Px水平均高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:甘草酸二铵胶囊联合肌苷片治疗老年药物性肝损伤患者可提高治疗总有效率,改善氧化应激指标水平,降低肝功能指标和炎性因子水平,效果优于单纯肌苷片治疗。

Objective:To observe effects of Diammonium glycyrrhizinate capsules combined with Inosine tablets in treatment of elderly patients with drug-induced liver injury.Methods:A prospective study was conducted on 68 elderly patients with drug-induced liver injury admitted to this hospital from January 2021 to January 2022.According to the random number table method,they were divided into control group and study group,34 cases in each group.The control group was treated with Inosine tablets,while the study group was treated with Diammonium glycyrrhizinate capsules on the basis of that of the control group.Both groups were treated continuously for 2 months.The clinical efficacy,the liver function indexes[alanine aminotransferase(ALT),total bilirubin(TBIL),aspartate aminotransferase(AST),alkaline phosphatase(ALP)]levels,the inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]levels,the oxidative stress indexes[malondialdehyde(MDA),glutathione peroxidase(GSH-Px),superoxide dismutase(SOD)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 97.06%(33/34),which was higher than 76.47%(26/34)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of ALT,AST,TBIL and ALP in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of CRP,IL-6 and TNF-αin the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the level of MDA in the study group was lower than that in the control group,the levels of SOD and GSH-Px were higher than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Diammonium glycyrrhizinate capsules combined with Inosine tablets in the treatment of the elderly patients with drug-induced liver injury can improve the total effective rate of treatment,improve the levels of oxidative stress indexes and reduce the levels of liver function indexes and the inflammatory factors.Moreover,it is superior to single Inosine tablets treatment.