银杏叶提取物联合倍他司汀治疗后循环缺血性眩晕患者的效果

Effects of Ginkgo biloba extract combined with Betahistine in treatment of patients with posterior circulation ischemic vertigo

目的:观察银杏叶提取物联合倍他司汀治疗后循环缺血性眩晕患者的效果。方法:选取2020年3月至2023年3月该院收治的120例后循环缺血性眩晕患者进行前瞻性研究,按照随机数字表法将其分为对照组和研究组各60例。对照组予以倍他司汀治疗,研究组在对照组基础上联合银杏叶提取物治疗,两组均连续治疗14 d。比较两组临床疗效,治疗前后脑动脉(左椎动脉、右椎动脉和基底动脉)血流速度、炎性因子[超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平,以及不良反应发生率。结果:研究组治疗总有效率为93.33%(56/60),高于对照组的80.00%(48/60),差异有统计学意义(P<0.05);治疗后,研究组左椎动脉、右椎动脉、基底动脉血流速度均高于对照组,差异有统计学意义(P<0.05);治疗后,研究组hs-CRP、IL-6、TNF-α水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:银杏叶提取物联合倍他司汀治疗后循环缺血性眩晕患者可提高治疗总有效率和脑动脉血流速度,降低炎性因子水平,效果优于单纯倍他司汀治疗。

Objective:To observe effects of Ginkgo biloba extract combined with Betahistine in treatment of patients with posterior circulation ischemic vertigo.Methods:A prospective study was conducted on 120 patients with posterior circulation ischemic vertigo admitted to this hospital from March 2020 to March 2023.According to the random number table method,they were divided into control group and study group,60 cases in each group.The control group was treated with Betahistine,while the study group was treated with Ginkgo biloba extract on the basis of that of the control group.Both groups were treated for 14 d.The clinical efficacy,the blood flow velocity of cerebral artery(left vertebral artery,right vertebral artery and basilar artery),the levels of inflammatory factors[high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 93.33%(56/60),which was higher than 80.00%(48/60)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the blood flow velocity of left vertebral artery,right vertebral artery and basilar artery in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of hs-CRP,IL-6 and TNF-αin the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Ginkgo biloba extract combined with Betahistine in the treatment of the patients with posterior circulation ischemic vertigo can improve the total effective rate of treatment and the cerebral artery blood flow velocity,and reduce the levels of inflammatory factors.Moreover,it is superior to single Betahistine treatment.