血清PCT、IL-17及Hb水平在老年肺部感染患者中的诊断价值

Diagnostic value of serum PCT,IL-17 and Hb levels in elderly patients with pulmonary i

目的:分析血清降钙素原(PCT)、白细胞介素-17(IL-17)及血红蛋白(Hb)水平在老年肺部感染患者中的诊断价值。方法:选取2021年6月至2022年10月该院收治的74例老年肺部感染患者,设为研究组,另选取同期50名健康体检者,设为对照组。比较两组PCT、IL-17及Hb水平,不同肺部感染程度患者的血清PCT、IL-17及Hb水平,并采用Pearson相关性分析血清PCT、IL-17及Hb水平与肺部感染程度的相关性;并绘制受试者工作特征(ROC)曲线,分析血清PCT、IL-17及Hb水平单项及联合检测诊断老年肺部感染的效能。结果:研究组血清PCT、IL-17水平均高于对照组,Hb水平低于对照组,差异有统计学意义(P<0.05);重、中度感染患者血清PCT、IL-17水平均高于轻度患者,且重度感染患者高于中度患者,重、中度感染患者Hb水平均低于轻度患者,且重度感染患者低于中度患者,差异有统计学意义(P<0.05);Pearson相关性分析结果显示,血清PCT、IL-17水平与肺部感染程度呈正相关(r>0,P<0.05),血清Hb水平与肺部感染程度呈负相关(r<0,P<0.05);ROC曲线结果显示,血清PCT、IL-17、Hb水平单项及联合检测诊断肺部感染的曲线下面积分别为0.780、0.762、0.781、0.897,均具有一定诊断效能,其中联合检测诊断效能最高。结论:血清PCT、IL-17水平与肺部感染程度呈正相关,血清Hb水平与肺部感染程度负相关,且血清PCT、IL-17及Hb水平联合检测诊断肺部感染的效能高于三者单项检测。

Objective:To analyze diagnostic value of serum procalcitonin(PCT),interleukin-17(IL-17)and hemoglobin(Hb)levels in elderly patients with pulmonary infection.Methods:A total of 74 elderly patients with pulmonary infection admitted to the hospital from June 2021 to October 2022 were selected as the study group,and 50 healthy subjects in the same period were selected as the control group.The levels of PCT,IL-17 and Hb in the two groups were compared,and the levels of serum PCT,IL-17 and Hb in the patients with different degrees of pulmonary infection were compared.Pearson correlation analysis was used to analyze the correlations among the serum PCT,IL-17 and Hb levels and the degree of pulmonary infection.The receiver operating characteristic(ROC)curve was drawn to analyze the efficiency of single and combined detection of serum PCT,IL-17 and Hb levels in the diagnosis of pulmonary infection in the elderly patients.Results:The levels of serum PCT and IL-17 in the study group were higher than those in the control group,the Hb level was lower than that in the control group,and the differences were statistically significant(P<0.05).The levels of serum PCT and IL-17 in the severe and moderate pulmonary infection patients were higher than those in the mild patients,and those in the severe pulmonary infection patients were higher than those in the moderate patients;the levels of Hb in the severe and moderate pulmonary infection patients were lower than those in the mild patients,and those in the severe group were lower than those in the moderate patients;and the differences were statistically significant(P<0.05).Pearson correlation analysis showed that the serum PCT and IL-17 levels were positively correlated with the degree of pulmonary infection(r>0,P<0.05),and the serum Hb level was negatively correlated with the degree of pulmonary infection(r<0,P<0.05).The ROC curve showed that the area under the curve of single and combined detection of serum PCT,IL-17 and Hb levels in the diagnosis of pulmonary infection were 0.780,0.762,0.781 and 0.897,separately,all of which had certain diagnostic efficiency,and the combined detection had the highest diagnostic efficiency in the diagnosis of pulmonary infection in the elderly patients.Conclusions:The levels of serum PCT and IL-17 are positively correlated with the degree of pulmonary infection,and the level of serum Hb is negatively correlated with the degree of pulmonary infection.The efficiency of combined detection of serum PCT,IL-17 and Hb in the diagnosis of pulmonary infection is higher than that of single detection of the three.