肺癌恶性胸腔积液患者外周血中肿瘤标志物Hsp90α的表达水平及其预后评估

Expression level of tumor marker Hsp90αin peripheral blood of patients with malignant pleural effusion of lung cancer and its prognosis assessment

目的分析肺癌恶性胸腔积液患者外周血中肿瘤标志物热休克蛋白90α(Hsp90α)的表达水平及其对预后的评估作用。方法选取安徽省阜阳市人民医院2018年1月至2021年1月收治的80例肺癌合并恶性胸腔积液患者作为A组,另选取同期安徽省阜阳市人民医院收治的80例良性胸腔积液患者作为B组及体检的80名健康者作为C组纳入研究。采用酶联免疫吸附试验检测三组外周血中肿瘤标志物Hsp90α表达水平。Kaplan-Meier法评估Hsp90α的表达与肺癌恶性胸腔积液患者预后的关系。结果三组外周血中肿瘤标志物Hsp90α表达比较,差异有统计学意义(P<0.05)。其中A组、B组外周血中肿瘤标志物Hsp90α表达高于C组,A组高于B组,差异有统计学意义(P<0.05)。不同年龄、性别、肿瘤直径、临床分期、淋巴结转移、病理分级及是否吸烟的肺癌恶性胸腔积液患者外周血中肿瘤标志物Hsp90α表达水平比较,差异无统计学意义(P>0.05)。Hsp90α高表达组的OS和RFS低于低表达组(P<0.05)。结论肺癌恶性胸腔积液患者外周血中肿瘤标志物Hsp90α水平明显升高,且其水平与预后生存状况具有紧密相关性,可将其作为肺癌恶性胸腔积液患者诊断、预后的重要指标。

Objective To analyze the expression level of heat shock protein 90α(Hsp90α)in peripheral blood of patients with malignant pleural effusion of lung cancer and its prognostic effect.Methods A total of 80 patients with lung cancer combined with malignant pleural effusion admitted to Fuyang People’s Hospital in Anhui Province from January 2018 to January 2021 were selected as group A,a total of 80 patients with benign pleural effusion admitted to Fuyang People’s Hospital in Anhui Province during the same period were selected as group B and a total of 80 healthy subjects who underwent physical examination were selected as group C.The expression level of tumor marker Hsp90αin peripheral blood of the three groups was detected by enzyme-linked immunosorbent assay.Kaplan-Meier method evaluated the relationship between the expression of Hsp90αand the prognosis of patients with malignant pleural effusion of lung cancer.Results The expression of tumor marker Hsp90αin peripheral blood of the three groups was statistically significant(P<0.05).The expression of tumor marker Hsp90αin peripheral blood of groups A and B were higher than that of group C,and group A was higher than group B,with statistical significance(P<0.05).There was no statistical significance in the expression level of tumor marker Hsp90αin peripheral blood of patients with malignant pleural effusion of lung cancer with different age,gender,tumor diameter,clinical stage,lymph node metastasis,pathological grade,and smoking status(P>0.05).The OS and RFS of Hsp90αin high group were lower than those in lowɑgroup(P<0.05).Conclusion The level of tumor marker Hsp90αin the peripheral blood of patients with malignant pleural effusion of lung cancer was significantly increased,and its level was closely correlated with the prognosis and survival status,which can be used as an important indicator for the diagnosis and prognosis of patients with malignant pleural effusion of lung cancer.