盐酸氨溴索注射液治疗新生儿肺炎的效果及对血清MMP-9、SIL-2R、NF-κB水平的影响

Therapeutic effect of ambroxol hydrochloride injection on neonatal pneumonia and the influence on serum levels of MMP-9,sIL-2R and NF-κB

目的分析盐酸氨溴索注射液治疗新生儿肺炎的疗效及对血清基质金属蛋白酶9(MMP-9)、可溶性白细胞介素-2受体(sIL-2R)、核转录因子-κB(NF-κB)水平的影响。方法抽取2020年1月至2022年7月郑州大学附属洛阳中心医院收治的新生儿肺炎患儿72例纳入研究,采用随机数字表法分为研究组与对照组,每组36例。对照组接受常规治疗,研究组在常规治疗基础上联用盐酸氨溴索注射液,两组均治疗7 d。比较两组治疗前后MMP-9、sIL-2R、NF-κB水平、体液免疫、血气指标及呼吸频率(RR),比较两组治疗效果。结果治疗7 d后,两组血清MMP-9、sIL-2R、NF-κB、RR、二氧化碳分压水平均低于治疗前,且研究组低于对照组(P<0.05)。治疗7 d后,两组血清免疫球蛋白A、免疫球蛋白M、免疫球蛋白G、动脉血氧分压水平均高于治疗前,且研究组高于对照组(P<0.05)。研究组总有效率(94.44%,34/36)高于对照组(77.78%,28/36),P<0.05。结论盐酸氨溴索注射液治疗新生儿肺炎的疗效较好,可降低血清MMP-9、sIL-2R、NF-κB表达,改善体液免疫,调节血气指标及呼吸频率。

Objective To analyze the therapeutic effect of ambroxol hydrochloride injection on neonatal pneumonia and its influence on serum levels of matrix metalloproteinase 9(MMP-9),soluble interleukin-2 receptor(sIL-2R)and nuclear transcription factor-κB(NF-κB).Methods A total of 72 children with neonatal pneumonia treated in Luoyang Central Hospital Affiliated to Zhengzhou University from January 2020 to July 2022 were selected and included in the study,and they were divided into study group and control group by random number table method,with 36 cases in each group.The control group received conventional treatment,and the study group was treated with ambroxol hydrochloride injection based on conventional treatment.Both groups were treated for 7 days.The serum levels of MMP-9,sIL-2R,NF-κB,humoral immunity,blood gas indexes and respiratory rate(RR)were compared between the two groups before and after treatment.The effective rate of the two groups were compared.Results After 7 days of treatment,the serum levels of MMP-9,sIL-2R,NF-κB,RR and partial pressure of carbon dioxide in the two groups decreased,and the above indexes in the study group were lower than those in the control group(P<0.05).After 7 days of treatment,serum levels of immunoglobulin A,immunoglobulin M,immunoglobulin G and arterial blood oxygen partial pressure in the two groups were higher than preoperative levels,moreover,the above indexes in the study group were higher than those in the control group(P<0.05).The total effective rate of the study group(94.44%,34/36)was higher than that of the control group(77.78%,28/36),P<0.05.Conclusions Ambroxol hydrochloride injection is effective in the treatment of neonatal pneumonia.It could reduce the expression of MMP-9,SIL-2R and NF-κB,improve humoral immunity,and regulate blood gas indexes and RR.