中西医结合治疗重症肺炎致呼吸衰竭的效果分析

Efficacy of integrated traditional Chinese and western medicine on respiratory failure caused by severe pneumonia

目的探讨中西医结合治疗重症肺炎致呼吸衰竭的效果。方法前瞻性随机对照研究。抽取2021年2月至2023年2月于河南中医药大学第一附属医院住院治疗的30例重症肺炎致呼吸衰竭患者,以随机数字表法分为对照组和观察组,每组15例。对照组接受传统西医治疗,观察组在传统西医治疗的基础上加用中医辨证论治。比较两组患者的临床疗效、呼吸功能[呼吸频率(R)、指脉氧饱和度(SpO_(2))、动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))]、炎症指标[白细胞计数、C-反应蛋白(CRP)]水平和不良反应发生情况。结果观察组治疗总有效比例为15/15,优于对照组的11/15(P=0.032)。治疗后,两组R、PaCO_(2)均低于治疗前,SpO_(2)、PaO_(2)均高于治疗前(P均<0.05)。治疗后,观察组R、PaCO_(2)均低于对照组,SpO_(2)、PaO_(2)均高于对照组(P均<0.05)。治疗后,观察组白细胞计数、CRP低于治疗前,且低于对照组(P<0.05)。两组患者不良反应发生率比较差异未见统计学意义(P>0.05)。结论中西医结合治疗重症肺炎致呼吸衰竭的疗效显著,不良反应少。

Objective To investigate the effect of integrated traditional Chinese and western medicine in the treatment of respiratory failure caused by severe pneumonia.Methods This study was a prospective randomized controlled study.Thirty patients with respiratory failure caused by severe pneumonia who were hospitalized in the First Affiliated Hospital of Henan University of Chinese Medicine from February 2021 to February 2023 were selected.And they were divided into control group and observation group by random number table method,with 15 cases in each group.The control group was treated with traditional western medicine,and the observation group was treated with traditional Chinese medicine treatment on the basis of syndrome differentiation combined with traditional western medicine.The clinical efficacy,respiratory function assessed by respiratory rate(R),finger pulse oxygen saturation(SpO_(2)),arterial oxygen partial pressure(PaO_(2))and arterial carbon dioxide partial pressure(PaCO_(2)),levels of inflammatory indicators,including white blood cell count and C-reactive protein(CRP),and incidence of adverse reactions were compared between the two groups.Results The total effective ratio of the observation group was 15/15,which was better than the 11/15 of the control group(P=0.032).After treatment,R and PaCO_(2) in both groups were lower than those before treatment,while SpO_(2) and PaO_(2) were higher than those before treatment(all P<0.05).After treatment,the levels of R and PaCO_(2) in the observation group were lower than those in the control group,while levels of SpO_(2) and PaO_(2) were higher than those in the control group(all P<0.05).After treatment,the white blood cell count and CRP in the observation group decreased,which were lower than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions Combined traditional Chinese and western medicine has a significant effect and less adverse reaction in the treatment of severe pneumonia caused by respiratory failure.