低分子肝素钠联合硝苯地平、硫酸镁治疗妊娠期高血压疾病的效果

Effect of low molecular weight heparin sodium combined with nifedipine and magnesium sulfate on pregnancyinduced hypertension

目的分析低分子肝素钠联合硝苯地平、硫酸镁治疗妊娠期高血压疾病(PIH)的效果。方法选取107例PIH患者为研究对象,按随机数字表法分成对照组及研究组。对照组55例采用硝苯地平联合硫酸镁治疗,研究组52例在此基础上采用低分子肝素钠治疗。比较两组患者的疗效、不良反应发生情况、血压水平及母婴妊娠结局。结果研究组治疗总有效率为96.2%,高于对照组的83.6%(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。治疗后,研究组血压明显低于对照组(P<0.05)。研究组母婴不良结局发生率低于对照组(P<0.05)。结论低分子肝素钠联合硝苯地平、硫酸镁治疗PIH可提高疗效,降低患者血压水平及妊娠不良结局的发生。

Objective To analyze the effect of low molecular weight heparin sodium combined with nifedipine and magnesium sulfate in the treatment of pregnancy-induced hypertension(PIH).Methods 107 patients with PIH were selected as study objects and were divided into a control group and a study group according to random number table method.55 cases in the control group were treated with nifedipine combined with magnesium sulfate,and 52 cases in the study group were treated with low molecular weight heparin sodium on this basis.The efficacy,occurrence of adverse reactions,blood pressure level and maternal and infant pregnancy outcome were compared between the two groups.Results The total effective rate of the study group was 96.2%,which was higher than that of the control group 83.6%(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).After treatment,the blood pressure of the study group was significantly lower than that of the control group(P<0.05).The incidence of adverse outcomes in the study group was lower than that in the control group(P<o.05).Conclusion Low molecular weight heparin sodium combined with nifedipine and magnesium sulfate in the treatment of PIH can improve the curative effect,reduce the levels of blood pressure and the occurrence of adverse pregnancy outcomes.