化浊通络定眩汤联合氟桂利嗪胶囊对后循环缺血性眩晕症患者疗效及对脑血流量的影响

Efficacy of Huazhuo Tongluo Dingxuan decoction combined with flunarizine capsule on patients with posterior circulation ischemic vertigo and its influence on cerebral blood flow

目的:观察化浊通络定眩汤联合氟桂利嗪胶囊对后循环缺血性眩晕症患者疗效及对脑血流量的影响。方法:选取2019年1月~2022年10月来我院治疗的80例后循环缺血性眩晕症患者为研究对象,依照区组随机化分组法将其分为西医组(n=40)和中医组(n=40)。西医组使用氟桂利嗪胶囊治疗,中医组在西医组基础上联合化浊通络定眩汤治疗。比较两组临床疗效及治疗前后中医证候积分,观察治疗前后两组脑血流量(全脑血流量、椎动脉血流速度、基底动脉血流速度),统计治疗期间两组不良反应发生率。结果:治疗后,中医组临床疗效优于西医组(P<0.05),两组总有效率比较无统计学差异(P>0.05);两组中医证候积分较治疗前均有降低(P<0.05),且中医组低于西医组(P<0.05);两组全脑血流量、椎动脉血流速度、基底动脉血流速度较治疗前均有升高(P<0.05),且中医组高于西医组(P<0.05)。治疗期间,两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:化浊通络定眩汤联合氟桂利嗪胶囊可提高后循环缺血性眩晕症患者治疗效果,改善患者临床体征和脑血流量情况,且安全性较高。

Objective:To observe the efficacy of Huazhuo Tongluo Dingxuan decoction combined with flunarizine capsule in treating patients with posterior circulation ischemic vertigo and its influence on cerebral blood flow.Methods:80 patients with posterior circulation ischemic vertigo treated in the hospital from January 2019 to October 2022 were selected as the study subjects and were divided into western medicine group(n=40)and traditional Chinese medicine group(n=40)according to the block randomization method.The western medicine group was treated with flunarizine capsule,and the traditional Chinese medicine group was given Huazhuo Tongluo Dingxuan decoction on the basis of the western medicine group.The clinical efficacy and TCM syndrome integral before treatment and after of treatment were compared between the two groups.The cerebral blood flow indicators(total cerebral blood flow,vertebral artery blood flow velocity,basilar artery blood flow velocity)in the two groups were observed before treatment and after of treatment,and the incidence rates of adverse reactions in the two groups were statistically analyzed within of treatment.Results:After of treatment,the clinical efficacy in traditional Chinese medicine group was better than that in western medicine group(P<0.05),but there was no statistical difference in the total effective rate between the two groups(P>0.05).The TCM syndrome integral in both groups were reduced compared with those before treatment(P<0.05),and the scores were lower in traditional Chinese medicine group than those in western medicine group(P<0.05).The total cerebral blood flow,vertebral artery blood flow velocity and basilar artery blood flow velocity were increased in both groups compared to before treatment(P<0.05),and the indicators in traditional Chinese medicine group were higher than those in western medicine group(P<0.05).Within of treatment,there were no statistically significant differences in the incidence rates of adverse reactions between the two groups(P>0.05).Conclusion:Huazhuo Tongluo Dingxuan decoction combined with flunarizine capsule can enhance the therapeutic effect,and improve the clinical signs and cerebral blood flow of patients with posterior circulation ischemic vertigo,and it has high safety.