脾虚湿阻证生物标志物的组学技术研究进展

Research progress of omics technology on biomarkers of Spleen deficiency and dampness stagnation syndrome

“诸湿肿满,皆属于脾”。脾虚导致湿邪中阻,进而引起代谢综合征、溃疡性结肠炎、癌症等多种疾病,病情多反复缠绵难愈。目前组学技术广泛运用于中医药证候相关生物标志物的研究,本文系统综述了采用代谢组学、蛋白质组学、基因组学、转录组学、以及肠道微生物组学等技术手段研究脾虚湿阻证标志物研究进展,以期为脾虚湿阻证的证候实质提供线索。

“All dampness and swelling belong to the spleen”.Spleen deficiency leads to dampness evil blocking and then causes many diseases,including metabolic syndrome,ulcerative colitis,cancer and so on.At present,multi-omics technology is widely used in the research of biomarkers related to TCM syndromes.This paper systematically reviewed the research progress of biomarkers related to spleen deficiency and dampness stagnation syndrome using metabonomics,proteomics,genomics,transcriptomics,intestinal microbiome and other technical means,with a view to providing clues for the essence of spleen deficiency and dampness stagnation syndrome.