动脉粥样硬化细胞免疫机制及其靶向治疗的研究进展

Research progress of cellular immune mechanisms in atherosclerotic and its targeted therapeutic strategies

动脉粥样硬化(AS)是一种慢性炎症性血管疾病。随着我国经济发展及生活水平的提高,AS患者年轻化,已成为严重危害我国人民健康和生活质量的疾病之一。免疫细胞在AS的发生发展中起着关键作用,因此免疫细胞靶向治疗AS是一种有前景的治疗策略。本文总结了T细胞、B细胞、巨噬细胞、树突细胞及中性粒细胞在AS发生发展中的作用并针对免疫细胞靶向治疗AS的策略进行了综述。

Atherosclerosis(AS)is a chronic inflammatory vascular disease.With the development of economy and the improvement of living standards in our country,AS patients with young people have become one of the diseases seriously endangering people's health and quality of life in our country.Immune cells play a key role in the occurrence and development of AS,so the targeted treatment of immune cells for AS is a promising therapeutic strategy.This review summarize the role of T cells,B cells,macrophages,dendritic cells and neutrophils in the occurrence and development of AS,and review the strategies for the targeted treatment of AS by immune cells.