齐拉西酮联合碳酸锂治疗对双相情感障碍躁狂发作患者的临床疗效

Clinical Effects of Ziprasidone Combined with Lithium Carbonate Therapy in Patients with Manic Episodes of Bipolar Disorder

目的:探讨齐拉西酮联合碳酸锂治疗对双相情感障碍躁狂发作患者躁狂量表(BRMS)评分、复发率及认知功能的影响.方法:选取2018年1月至2022年1月本院收治的100例双相情感障碍躁狂发作患者作为研究对象.根据治疗方案不同分将其为观察组(n=47,口服碳酸锂缓释片+盐酸齐拉西酮胶囊)和对照组(n=53,口服碳酸锂缓释片).比较两组患者治疗效果、复发率及认知功能.结果:治疗后,两组BRMS,杨氏躁狂评定量表(YMRS)评分,均明显下降,观察组BRMS、YMRS评分下降幅度显著大于对照组,差异均有统计学意义(P<0.05);治疗后,两组患者简明精神状态检查量表(MMSE)各指标得分,均明显升高,观察组显著高于对照组,差异均有统计学意义(P<0.05);观察组复发率(2.13%,1/47)低于对照组(13.21%,7/53),差异有统计学意义(P<0.05).结论:齐拉西酮联合碳酸锂治疗双相情感障碍躁狂发作临床疗效更佳,是一种安全可靠的治疗方案.

Objective:To investigate the effects of ziprasidone combined with lithium carbonate therapy on bipolar disorder score,relapse rate and cognitive function in patients with manic episodes of bipolar disorder.Methods:A total of 100 patients with manic episodes of bipolar disorder in our hospital from January 2018 to January 2022 were selected in this study.According to different treatment strategies,they were divided into observation group(n=47,oral lithium carbonate sustained-release tablets and ziprasidone hydrochloride capsules)and control group(n=47,oral lithium carbonate sustained-release tablets only).The treatment efficacy,recurrence rate,and cognitive function were compared between two groups.Results:After treatment,the scores of Bech-Rafaelsen mania rating scale(BRMS)and Young mania rating scale(YMRS)in the two groups were significantly decreased,the scores of BRMS and YMRS in the observation group were significantly lower than those of the control group,there were significant dfferences(P<0.05).After treatment,the scores of the MMSE scale in the two groups were significantly increased,and the observation group was significantly higher than that of the control group,there was significant differences(P<O.05).The recurrence rate of the observation group(2.13%,1/47)was significantly lower than that of the control group(13.21%,7/53).Conclusion:The clinical efficacy of ziprasidone combined with lithium carbonate in the treatment of manic episodes in bipolar disorder is better than treatment by oral lithium carbonate sustained-release tablets only,which is a safe and reliable treatment strategy.