摘要
目的:观察柴郁清肝汤治疗非酒精性脂肪性肝病(NAFLD)肝郁脾虚证患者的临床疗效及对外周血Th17/Treg和相关炎症因子的影响。方法:将60例NAFLD患者随机分为观察组(30例)和对照组(30例),其中观察组给予柴郁清肝汤治疗,对照组给予维生素E软胶囊治疗,治疗8周评价疗效;分别观察2组患者治疗前后肝功、血脂、外周血T淋巴细胞Th17、Treg的百分比及其相关炎症因子(IL-17、IL-22、IL-10)的变化。结果:治疗8周,观察组显效16例,有效12例,对照组显效8例,有效13例,2组比较差异具有统计学意义(P<0.05)。与治疗前比较,2组患者ALT、AST、GGT、ALP、TC、TG、LDL-C、Th17、IL-17和IL-22明显降低,Treg明显升高,差异具有统计学意义(P<0.05),2组间比较观察组均明显优于对照组(P<0.05)。结论:柴郁清肝汤能够有效治疗NAFLD患者,改善肝功能和血脂,调节Th17/Treg平衡及其相关炎性因子分泌是其作用机制之一。
Objective:To observe the clinical effect of Chaiyu Qinggan Decoction on nonalcoholic fatty liver disease(NAFLD)patients with liver stagnation and spleen deficiency syndrome and its effects on Th17/Treg in peripheral blood and serum inflammatory factors.Methods:60 patients with NAFLD were randomly divided into observation group(30 cases)and control group(30 cases).The observation group was treated with Chaiyu Qinggan Decoction,and the control group was treated with Vitamin E soft capsule,they were treated for 8 weeks,the curative effect was evaluated,The liver function,blood lipid,inflammatory factors(IL-17,IL-22)and the percentage of Th17 and Treg in peripheral blood T lymphocytes were observed before and after treatment in the two groups.Results:After treatment for 8 weeks,16 cases were markedly effective and 12 cases were effective in the observation group,and 8 cases were markedly effective and 13 cases were effective in the control group,the difference of effect between the two groups was statistically significant(P<0.05).Compared with before treatment,ALT,AST,GGT,ALP,TC,TG,LDL-C,Th17,IL-17 and IL-22 in the two groups were significantly decreased,Treg was significantly increased,and the difference was statistically significant(P<0.05).The effects of observation group were significantly better than those in the control group,and the diffe-rences were statistically significant(P<0.05).Conclusion:Chaiyu Qinggan Decoction can effectively treat NAFLD patients,improve liver function and blood lipids,regulating the balance of Th17/Treg and the secretion of related inflammatory factors is one of the mechanisms.
作者
张雅丽
雷智勇
高婷婷
高佳炜
杨柳欣
袁星星
ZHANG Yali;LEI Zhiyong;GAO Tingting;GAO Jiawei;YANG Liuxin;YUAN Xingxing(Heilongjiang Academy of Chinese Medicine Sciences,Harbin,Heilongjiang 150036;ZHANG Yali Famous Old Chinese Medicine Expert Studio,Harbin,Heilongjiang 150006;Heilongjiang University of Chinese Medicine,Harbin,Heilongjiang 150040)
出处
《中国中医药科技》
CAS
2024年第2期196-199,共4页
Chinese Journal of Traditional Medical Science and Technology
基金
黑龙江省中医药科研项目(ZHY2022-080)。