多囊卵巢综合征患者代谢功能的基础研究进展

Research progress on metabolic function in patients with polycystic ovary syndrome

不孕不育疾病的发病率逐年递增,影响全球约12%~15%的育龄期女性,多囊卵巢综合征(polycystic ovary syndrome, PCOS)是不孕症常见的病因之一。近年来,PCOS的发病率逐年上升,但PCOS患者的内分泌、代谢功能紊乱改善及妊娠结局不理想。国内外共识一致认为,改善PCOS患者的代谢功能以及内分泌异常可提高患者妊娠率。因此探索PCOS患者的代谢功能改善具有重要意义。此文就改善PCOS患者代谢功能的基础研究进展进行综述。

The incidence of infertility disorders is increasing year by year,affecting about 12-15%of women of reproductive age worldwide.Polycystic ovary syndrome(PCOS)is one of the common causes of infertility.In recent years,the incidence rate of PCOS has increased year by year,but the improvement of endocrine and metabolic dysfunction and pregnancy outcomes in patients with PCOS are not satisfactory.There is a consensus both domestically and internationally that improving metabolic function and endocrine abnormalities in PCOS patients can increase their pregnancy rate.Therefore,it is important to explore the improvement of metabolic function in patients with PCOS.This article reviews the progress of basic research on improving metabolic function in patients with PCOS.